Feasibility study of high field 3.0T multiparametric magnetic resonance imaging for local staging of invasive urinary bladder tumours

Several imaging techniques may be used to further specify the extent of the
local tumour, e.g. ultrasound of the bladder, CT-urography (CT-IVU) or magnetic
resonance imaging (MRI). The CT-scan may give a reasonable impression on the
tissue surrounding the bladder and potential lymphadenopathy but is
insufficient to adequately stage the primary bladder tumour. In recent years
some studies have reported an improvement of local bladder tumour staging, by
means of magnetic resonance imaging (MRI).
Currently the planning of external beam radiotherapy (EBRT) for bladder tumours
is based on CT-imaging. To increase the accuracy of GTV planning, MRI may be
used. Furthermore, in the near future, the use of the MRI-Linac system for real
time and on-line MRI guidance of external beam radiotherapy may be used for
correction of bladder movement during radiotherapy.

-To demonstrate the value of MRI in the initial staging of bladder tumours
-To evaluate the feasibility of the use of MRI to delineate bladder tumours for
planning GTV for external beam radiotherapy

This is an observational study to analyse bladder tumour staging with
multiparametric magnetic resonance imaging in patients with a known bladder
tumour, who are planned for radical cystectomy.
Patients will be accrued during their visit to the outpatient department of
urology. They will undergo the routine laboratory tests (including serum
Creatinin) and CT-IVU investigations and subsequently a multiparametric
MRI-scan.

Prior to surgery a diffusion weighted contrast enhanced 3-Tesla MRI-scan will
be made.
The risks and burden are minimal.