The primary objective is to investigate the neural correlates of the integration of multisensory information in adolescents with ASD.
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference between individuals with ASD and healthy volunteers with respect
to the underlying mechanisms of multisensory integration. In Experiment 1 the
parameter is the modulation of the auditory-evoked N1 component of the
event-related potential by motor-auditory prediction. In Experiment 2 the
parameter is the modulation of the auditory-evoked N1/P2 components of the
event-related potential by visual-auditory prediction. In Experiment 3 the
parameter is the modulation of stimulus omission responses, induced by
motor-auditory prediction. In Experiment 4 the parameter is the modulation of
stimulus omission responses, induced by visual-auditory prediction. In
Experiment 5 the parameter is the audiovisual (McGurk) mismatch negativity. In
Experiment 6 the parameters are mid-latency potentials associated with the
multisensory gain of speech in noise.
Secondary outcome
n/a
Background summary
The earliest as well as the most current theories of autism are based on the
premise that individuals with ASD process sensory information in a way that is
different from others. Here, we investigate whether the interaction between the
senses are impaired or atypical in ASD. The primary objective is to investigate
audiovisual perception in autistic individuals on the behavioral and neural
level, using electroencephalography (EEG). Do autistic individuals differ from
healthy controls in the brain mechanisms underlying audiovisual integration?
Are impairments of autistic individuals in audiovisual integration as measured
on the behavioural level linked to specific patterns in neural activity? The
experiments will provide insight in the (neural) mechanisms of the deficits in
audiovisual integration in autism.
Study objective
The primary objective is to investigate the neural correlates of the
integration of multisensory information in adolescents with ASD.
Study design
Six separate counterbalanced quasi-experimental EEG experiments investigating
multisensory integration.
Study burden and risks
The participants are seated in a comfortable chair, wear a cap containing
sensors and are tested for a total of at most 1.5 hours each time in a dimly
lit room. The task is to watch a monitor while auditory and visual stimuli are
presented. Participants have to react to stimuli with a button press. The risks
are negligible and the burden minimal. The study adds to our understanding of
the processes underlying the (sensory) problems associated with ASD and could
not be conducted without the participation of adolescents with autism.
Hellingen 21
Dordrecht 3300 AT
NL
Hellingen 21
Dordrecht 3300 AT
NL
Listed location countries
Age
Inclusion criteria
-Presence of an autism spectrum disorder (ASD; Autism, Pervasive Developmental
Disorder) according to the DSM-IV-TR criteria for autism, diagnosed by a
professional clinical team (added with an score of the Autism Diagnostic
Observation Scale (ADOS) which is administered by certified raters)
-Age between 14 and 21 years
-Normal hearing and normal or corrected to normal vision
-Written consent by parents or caregivers and adolescent
Exclusion criteria
-Evidence of a serious medical, neurological or psychiatric illness (apart from
ASD), seizure disorders, trauma or a use of medications affecting the nervous
system
-learning disabilities
-mental retardation
-language delays
-head trauma
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL52250.028.15 |