Primary objective is to examine the effect of acetaminophen on the cardiac deceleration associated with the painful experience of social rejection.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Gezonde proefpersonen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cardiac deceleration following unexpected social rejection
Secondary outcome
Expectancy bias in terms of expected rejection events, P3 amplitude following
unexpected rejection and theta power following unexpected social rejection.
Subjectively reported crying behavior.
Background summary
Previous research has shown that social rejection is painful. Related research
has shown the painful experience of social exclusion and making mistakes can be
eased by acetaminophen (paracetamol). Therefore it would be interesting to see
whether acetaminophen can also ease the pain of social rejection.
Study objective
Primary objective is to examine the effect of acetaminophen on the cardiac
deceleration associated with the painful experience of social rejection.
Study design
Intervention study
Intervention
1000 mg paracetamol
Study burden and risks
Participants have to ingest two tablets containing either acetaminophen or
placebo. After ingesting these pills they have to wait for an hour. In this
hour participants complete a number of questionnaires. Finally, after the 1
hour waiting period participants perform a number of psychological tasks and
complete a second set of questionnaires. Acetaminophen is often used painkiller
with a low risk profile. Participants are screened for possible risk factors
for the use of acetaminophen (e.g. liver disease) and selected on the basis of
positive and successful experiences with the use of acetaminophen as a
painkiller. There are negligible risks associated with acetaminophen and
participants do not benefit from participation in another way than receiving a
small amount of money for their voluntary participation.
Burg. Oudlaan 50
Rotterdam 3062PA
NL
Burg. Oudlaan 50
Rotterdam 3062PA
NL
Listed location countries
Age
Inclusion criteria
1. Age between 18 and 30
2. Sufficient understanding of Dutch
Exclusion criteria
1. Cardiac, hepatic, renal, neurological or psychiatric disorders
2. Personal or family history of psychiatric Illness
3. Migraine
4. Drug use and medication use
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| EudraCT | EUCTR2017-004735-37-NL |
| CCMO | NL60549.078.17 |