To develop and validate a probabilistic subcortical atlas of a PD population using 7Tesla MRI, and to validate this atlas for use on 3T MRI data.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Obtained MRI data will be used to develop a probabilistic subcortical 7T atlas
of a PD population. We will measure signal to noise ratio, Dice coefficients,
Center of Gravity measurements, susceptibility values, and connectivity in
multiple subcortical brain structures. To validate and quantify the advantage
of using 7T over 3T scans, we will compare 7T and 3T results in the first year.
Secondary outcome
N.A.
Background summary
With the advent of ultra-high field (UHF) 7Tesla MRI imaging small structures
located deep in the brain can now for the first time be visualized providing a
high level of anatomical detail. In view of the increasing application of deep
brain stimulation (DBS) surgery targeting subcortical brain nuclei in
Parkinson*s Disease (PD) patients, it is now possible to develop a clinical
atlas of the human subcortex using ultra-high resolution MRI. In this study we
intend to collect and analyse MRI images from patients with PD that allow the
development of this atlas. To this end we will perform a prospective cohort
study in which we will obtain structural and resting state MR images using UHF
scans, as well as 3T MR images for clinical validation of the use of 7T MRI.
The atlas will be of significant value for application by neurosurgical centres
worldwide that do not have access to UHF MRI systems.
Study objective
To develop and validate a probabilistic subcortical atlas of a PD population
using 7Tesla MRI, and to validate this atlas for use on 3T MRI data.
Study design
Prospective cohort study
Study burden and risks
Participants will be contacted to assess their suitability to participate in
MRI research. Participants who meet the inclusion and none of the exclusion
criteria will be invited to the Spinoza Centre for neuroimaging. Their
eligibility to participate in MRI research will be confirmed and they will
undergo 7T MRI scanning. MRI is a safe non-invasive imaging procedure, which
does not use ionizing radiation and has low inherent risks. Ultra-high
resolution (7T) imaging has been applied to PD patients before and has proven
to be valuable in PD research. Participants will undergo additional 3T MRI
scanning. No serious adverse effects have been reported for 3T or 7T MRI
scanning.
For all participants, scans will be acquired during one 7T scan session of
approximately 60 minutes. In the first year, an additional 3T scan session of
approximately 45 minutes will be obtained. Scanning will in no way interfere
with clinical treatment and will result in minor discomfort for the patients.
Nieuwe Achtergracht 129
Amsterdam 1018WS
NL
Nieuwe Achtergracht 129
Amsterdam 1018WS
NL
Listed location countries
Age
Inclusion criteria
Age between 18 and 80 years old
Clinical diagnosis of Parkinson's disease based on self-reporting by the patient
Patients must be able to walk into the scanner room and climb onto the scanner bed
Current treatment with anti-Parkinson medication
Patients must meet the requirements to safely undergo MRI scanning, as determined using an MR-checklist, and a short interview
Signed informed consent
Exclusion criteria
A history of concomitant psychiatric or neurological disease, other than Parksinson's disease as well as a history of stroke or traumatic brain injury, as assessed by self reports
Claustrophobia
Implanted ferromagnetic particles
Any contra-indication for MRI research, as assessed by an MRI-checklist
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL61200.018.17 |