To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer.
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
- Miscellaneous and site unspecified neoplasms benign
- Respiratory tract neoplasms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main endpoint of this study is neural representations of taste stimuli.
Secondary outcome
Secondary endpoints are the relation between brain reward-related activity,
anorexia based on a dietary questionnaire and in LAHNSCC patients only, the
relation between taste perception and food reward related activity and degree
of recovery after chemoradiation (CRT).
Background summary
Cachexia, i.e. unintended loss of skeletal muscle- and fat mass, is common in
the cancer trajectory. Frequencies ranges up to 54% in lung cancer and 52% in
head and neck cancer, and 86% in pancreatic cancer. Cachexia is not only an
independent determinant of mortality but also influences tumor treatment and
greatly influences quality of life. Patients with cachexia are often
hypermetabolic, which should be compensated by dietary intake. However, it is
acknowledged that dietary intake is often insufficient to meet elevated energy
requirements, due to disease or treatment induced anorexia, i.e. loss of
appetite. Elucidating underlying mechanisms of disease induced anorexia may
provide new insights to optimize nutritional support in cachectic patients.
Study objective
To study activity in the reward-circuitry of the brain in patients suffering
from cachexia induced by cancer.
Study design
cross-sectional study
Study burden and risks
The effective radiator dose of the DEXA scan is, depending on the duration of
the scan (size of the body) between 0.001-0.007 mSv, which is neglectable in
comparison to the yearly natural background dose in The Netherlands, which is
1-2 mSv. The risks of fMRI-scanning are negligible because it is a magnetic
field, does not involve ionizing radiation and does not require contrast agents
or anesthesia. The other measurements and procedures have very low risks.
P Debyelaan 25 P Debyelaan 25
Maastricht 6202 AZ
NL
P Debyelaan 25 P Debyelaan 25
Maastricht 6202 AZ
NL
Listed location countries
Age
Inclusion criteria
Head and Neck Cancer (HNC) patients treated with concurrent chemoradiation or bioradiation with curative intent.
-Treatment completion 2-3 months ago
-70>= age >=18;Healthy controls
-Matched for age, gender, smoking behaviour, and scanning hour of the day.
Exclusion criteria
For all groups:
- Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up)
- Pregnancy
- Psychiatric or other disorders likely to impact on informed consent
- Presence of brain metastasis (screening is not mandatory)
- Medical history of cerebrovascular accident, brain tumour, brain metastasis
- Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy
- Memory problems
- Current use of tube feeding or parental nutrition
- Patients with an active second malignancy
- Patients unable to lie still for 2 hours
- Unable to complete the cognitive task in the imitation scanner
- Allergy to gluten-, milk- or wheat products
- Self-reported hyperthyroidism
- Current use of appetite stimulant medications
- Recurrent head and neck cancer (rHNC)
- Previously administered systemic anti-tumor therapy
- Reirradiation setting
- Analphabetic
- Mini mental state examination score <21
- Concurrent neurological disease (e.g. morbus Parkinson)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54799.068.15 |