The main objective of the study is to investigate the differences in brain activation between novices and experts (i.e. between persons with and without the misconception) when they are asked to judge a statement regarding a related displayed…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
n.v.t.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Physiology Concept Test scores will be used to determine the presence or
absence of the misconception. The functional MRI scan will give information
about task-related brain activity during the misconception task.
Secondary outcome
N/A.
Background summary
Few pedagogical strategies have been put forward to address students*
misconceptions in medical physiology. Despite the integration of physiology
courses in the medical curricula worldwide, alleviating misconceptions through
effective instructional designs remains a challenge, likely because the
underlying mechanisms remain poorly understood. Based on previous neuroimaging
research, we hypothesize that cognitive inhibition plays a key role in
overcoming misconceptions. Exploring this potential mechanism may provide
future directions for effective conceptual change instructions.
Study objective
The main objective of the study is to investigate the differences in brain
activation between novices and experts (i.e. between persons with and without
the misconception) when they are asked to judge a statement regarding a related
displayed physiological situation.
Study design
This is a non-interventional, observational MRI study. Prior to the MRI phase,
participants fill in a Physiology Concept Test. Based on these outcomes,
participants will be assigned to the *experts* or *novices* group. Inside the
MRI scanner, we will measure brain activation using functional MRI (fMRI) while
the participant is performing tasks related to misconception. In addition, we
will perform a standardized structural MRI of the brain for analyses purposes
(e.g., registration to standard space) to allow generalizability. All
measurements are non-invasive.
Study burden and risks
The MRI acquisition is non-invasive and there are no known risks associated
with participating in a MRI study. Some subjects may feel claustrophobic in the
restricted space of the MRI scanner. Claustrophobia from the MRI scan will be
reduced by explaining the nature of the scanner in detail before enrollment. At
all times, the subjects can request to be removed from the scanner.
Participants will be carefully screened for all contra-indications (e.g. metal
parts, pregnancy etc.). The investigator, physician and MRI safety team will
assess whether there are contra-indications for MRI, and decide whether or not
the participant is allowed to go into the scanner. Participants will be asked
to invest a maximum 1h of their time for the MRI procedure. All participants
will be allowed to withdraw from the study at any point in time. There is no
direct benefit to the participants. All participants will receive a
reimbursement of 20 euros for completion of this study.
Hippocratespad 21
Leiden 2300RC
NL
Hippocratespad 21
Leiden 2300RC
NL
Listed location countries
Age
Inclusion criteria
- Higher education level student
- Age 18-25 years
Exclusion criteria
- Participants with a history of neurological or psychiatric disorder or current use of psychotropic medications;- MRI * contraindication (e.g. cardiac pacemaker, implants not approved for MRI, claustrophobia or pregnant (or a chance of being pregnant (as reported by the participant). ;- Consumption of alcohol or any other drugs 24 hours prior to scanning.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68949.058.19 |