Prevalence of CeD is about 15 around the world with a variation from 1:100 to 1:300 in different geographical areas [2, 3]. The diagnosis is made out of case finding among at-risk population such as diarrhea, anemia, ibs-like abdominal complaints,…
ID
Source
Brief title
Condition
- Malabsorption conditions
- Autoimmune disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) to know the predictive value of serology in the diagnosis of CeD in a
high-risk population (seropositive or high clinical suspicion)
2) to determine the serology cut-off best suited to predict the presence of
small bowel duodenal damage diagnostic for CD (Marsh > 2 and Marsh 3
separately)
Secondary outcome
not applicable
Background summary
Coeliac disease (CeD) is a multifactorial, autoimmune, multiorgan disease that
occurs, upon the ingestion of gluten in genetically determined individuals.
The disease may present with a wide spectrum of symptoms and signs from the
overt, severe malabsorption syndrome to the asymptomatic form [1].
Study objective
Prevalence of CeD is about 15 around the world with a variation from 1:100 to
1:300 in different geographical areas [2, 3]. The diagnosis is made out of case
finding among at-risk population such as diarrhea, anemia, ibs-like abdominal
complaints, fatigue, other autoimmune diseases such as thyroiditis, ibs or
dyspepsia, relatives of a coeliac person with little or no symptoms at all,
iron deficiency anemia, fatigue.
In the suspicion of CeD, the presence of highly specific serum antibodies
supports the diagnosis. There are autoantibodies targeting the auto-antigen
such as Antiendomysial (EMA) and anti-tissue transglutaminase (anti-tTG)
antibodies and antibodies targeting the offending agent (gliadin) such as
antibodies against synthetic deamidated gliadin peptides (anti-DGPs)
Study design
prospective, multicentre, observational study
Study burden and risks
no extra risks
Koekoekslaan 1
Nieuwegein 3435cm
NL
Koekoekslaan 1
Nieuwegein 3435cm
NL
Listed location countries
Age
Inclusion criteria
indication for biopsy in suspected celiac disease
Exclusion criteria
nvt
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL69084.100.19 |