Gaining an objective insight in muscle fatigue during exercise for patients with NMD by1. comparing the timing of change in sEMG amplitude and sEMG median frequency, to gas exchange variables, heart rate, work load, muscle strength, muscular…
ID
Source
Brief title
Condition
- Musculoskeletal and connective tissue disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
sEMG amplitude
sEMG median frequency
Secondary outcome
3D movement analysis
spirometry (VO2 max, heart rate, anaerobic threshold, workolad, serum lactate
levels, Borg scale)
Muscle strength
Background summary
On average more than 60% of patients with a neuromuscular disorder
(NMD)experiences severe fatigue. Increasing the level of physical inactivity by
aerobic exercises or cognitive behavioural therapy leads to a lower level of
fatigue and a deceleration of the increase of fatty infiltration of upper leg
muscles in the majority of these patients. However, the effect of both
therapies on exercise tolerance is unknown. Current outcome measures for
exercise tolerance focus on the cardiovascular system by the use of
ergospirometry. For patients with a NMD , muscle fatigue generally is the
limiting
factor during exercise. One possible non-invasive alternative to objectively
measure muscle fatigue on the (neuro) muscular level could be the use of
surface electromyography (sEMG).
Study objective
Gaining an objective insight in muscle fatigue during exercise for patients
with NMD by
1. comparing the timing of change in sEMG amplitude and sEMG median frequency,
to gas exchange variables, heart rate, work load, muscle strength, muscular
oxidative capacity and blood lactate levels during a cycle test with a
constant and incremental workload en strength measurements of arms and legs
2. comparing the relative timing of change in sEMG amplitude and sEMG median
frequency in patients with NMD with
the relative timing of change in sEMG amplitude and sEMG median frequency in
healthy subjects
Study design
Explorative cross-sectional proof of concept pilot study
Study burden and risks
The burden and risks associated with participation are neglectable. The task
that need to be performed is safely
performed by healthy subjects and NMD patients before. CE marked equipment is
used.
Reinier postlaan 2
Nijmegen 6525 GC
NL
Reinier postlaan 2
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
- aged 18 years and older
- being able to read and understand the Dutch language
- mentally competent
- being able to cycle at least 8 minutes on a cycle leg and/ or arm ergometer
Exclusion criteria
- pregnancy
- cognitive impairment
- disabling co-morbidity interfering with the cycle test
- contraindications to Exercise Stress Testing according to the guidelines of the American Heart Association
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68723.091.19 |