We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH
ID
Source
Brief title
Condition
- Autoimmune disorders
- Ancillary infectious topics
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Immune reponse
Genetic variants
Secondary outcome
Characterisation of the patient population.
Background summary
Hemophagocytic lymphohistiocytosis (HLH) is a serious, life-threatening
dysregulation of the immune response. In children, genetic defects are known
that predispose to HLH. In adults in contrast, HLH occurs mostly secondary to
an underlying malignancy, auto-immune disease or infection. Little is known
about the predisposing factors for secondary HLH in adults, although genetic
factors may play a role. Because HLH is a rare disease, evidence is often
anecdotical. We hypothesize that in patients who survived HLH, long-lasting
immune defects can be identified that contributed to the dysregulated response.
Also, primary genetic variants previously described for primary in children,
might be find in these individuals.
Study objective
We aim to find immune defects and related genetic variants in patients who have
recovered from secondary HLH
Study design
Cohort study
Study burden and risks
Venapuncture
Time investment for patient visit
Geert Grooteplein Zuid 10
Nijmegen 6525GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525GA
NL
Listed location countries
Age
Inclusion criteria
Hemophagocytic lymphohistiocytosis (HLH) secondary to infection
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72329.091.19 |