To study the neural basis of i) general movements including the transition to the last phase of general movements, the fidgety movements, en ii) the transition from general movements into goal-directed movements using electromyography (EMG),…
ID
Source
Brief title
Condition
- Neurological disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle coordination patterns (EMG-activity): especially duration of bursts,
degree of antagonist co-activation and EMG-EMG coherence
Secondary outcome
Corticomuscular (EEG-EMG) coherence, and kinematic characteristics, especially
intra-limb joint angle correlation.
Background summary
General movements (GMs) are present from early fetal life until 3-5 months
corrected age. It is well known that the assessment of the quality of the GMs
has predictive value in identifying infants at risk of cerebral palsy (CP) and
other developmental disorders. Currently GM-quality is assessed by means of
human Gestalt analysis of video recordings of GMs. Little is known on the
neurodevelopmental organization, e.g., in terms of muscle coordination patterns
and cortical activity, underlying both the presence of GMs and the transition
of GMs to goal-directed activity.
Study objective
To study the neural basis of i) general movements including the transition to
the last phase of general movements, the fidgety movements, en ii) the
transition from general movements into goal-directed movements using
electromyography (EMG), electroencephalograpy (EEG) and 3D-kinematic video
data. This knowledge will facilitate the development of automatic movement
analysis systems.
Study design
Longitudinal cohort study
Study burden and risks
The infants will be assessed 4 four times (at 1, 3, 5 and 18 months of age *
the last assessment serves the documentation of developmental outcome). The
assessments will take place at the babylab at the Institute of Developmental
Neurology at the UMCG. If the infant is tired, crying or hungry, the assessment
is stopped. It is discussed with the parents whether it is possible to
reschedule the appointment at a later point in time. The data can only be
obtained by studying infants. Benefits of participation for infant and family
consist of getting detailed information on infant motor development in general
and on the infant*s current developmental status * if desired.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
Healthy full-term infants, i.e. an infant born after a gestational age of at least 37 weeks without prenatal, perinatal or neonatal complications, younger than 1 month of age (first assessment at age of 1 month).
Exclusion criteria
Infants will be excluded from the study in case of:
- severe congenital abnormalities, such as serious congenital heart disorders or a chromosomal condition
- birthweight below the tenth percentile
- neurological abnormalities
- parents have insufficient understanding of the Dutch language
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68295.042.19 |