Possible correlations between blood and sweat composition will be investigated. If these correlations exist, sweat composition can be related to phenomena like dehydration. In this way, invasive measurements may become unnecessary in elite sport and…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Geen aandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
[Na+], [K+], [Cl-], [NH3+], [lactate] in blood and sweat.
Secondary outcome
Level of fitness, age, sex, core temperature, heart rate, skin temperature,
subjective measures, whole body sweat rate, urine specific gravity (USG), food
intake.
Background summary
Development of smart wearables has never been as popular as it is nowadays. To
reduce the need for invasive and expensive measures of human biomarkers, there
is need for continuous and non-invasive measures. Thus far, sweat is the most
preferred bodily fluid to use for non-invasive measures, over blood for
instance. Sweat originates from the blood plasm. However, the correlation
between blood and sweat composition remains relatively unknown. The trajectory
from blood plasm to sweat at the skin surface therefore has to be investigated.
One can do this by investigating correlation between blood and sweat
composition while exercise intensity, for example, differs. Since the
relationship between important constituents of blood and phenomena like
dehydration is known, the possibly found correlations may link sweat
composition to these phenomena.
Study objective
Possible correlations between blood and sweat composition will be investigated.
If these correlations exist, sweat composition can be related to phenomena like
dehydration. In this way, invasive measurements may become unnecessary in elite
sport and health settings.
Study design
The study consists of 2 measurements at the Vrije Universiteit Amsterdam.
During visit 1 participants* maximal oxygen capacity (VO2 max) will be
determined by performing a maximal cycling test in a thermo-neutral condition.
The second visit will be an incremental cycling protocol in the climatic
chamber, set at 30°C, 30% RH. During this second visit 15 blood and 10 sweat
samples will be collected. Physiological parameters body temperature, skin
temperature, heart rate and sweat rate will be monitored continuously.
Study burden and risks
It is possible that participants feel warm or uncomfortable during the
measurements. To prevent any risk body temperature, heart rate and subjective
measures are carefully and continuously monitored. Besides, the experiment will
be quit if body temperature exceeds 39.5 °C. The experiment will also be
discontinued if the participant feels dizzy or nauseous.
Van der Boechorststraat 7
Amsterdam 1081BT
NL
Van der Boechorststraat 7
Amsterdam 1081BT
NL
Listed location countries
Age
Inclusion criteria
- 18-40 years old
- Generally healthy: no cardiac problems (according to NYHA classification), no
high blood pressure, no fever or infection, no psychiatric problems, no liver
and kidney problems
- Command of the Dutch language
- Fit (actively taking part in sports 3 times a week)
- Body mass index (BMI) 20-25 kg/m2
- Veins suitable for blood sampling at the inspection
- Based on the outcome of the anamnesis form, participants should be rated as
low-risk participants
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Underage
- Older than 40 years
- Smoking
- Use of hard drugs
- Use of specific medicines:
* Chronic use of NSAIDs: aspirin, ibuprofen, corticosteroids
* Drugs for gastric and intestinal function
* Drugs for heart and coronary diseases
- Blood donation six weeks prior to the start of the study
- Pregnancy or breastfeeding
- Sweat pattern condition: hyperhidrosis, hypohidrosis or anhidrosis
- No low-risk classification based on the outcome of the anamnesis form (see
appendix xxx)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL69095.078.19 |