The present study aims at examining the effects of DBS on speaking. We will test participants performing a verbal fluency task but also producing spontaneous language and performing a language task that is dependent on a brain area targeted by DBS.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Behavioural performance on the language tasks for the different ON-OFF states
of stimulation and medication
Secondary outcome
NA
Background summary
Deep brain stimulation (DBS) of the subthalamic nucleus is indicated for
Parkinson*s disease (PD) patients who no longer respond (optimally) to
medication and it has been shown to effectively alleviate motor symptoms in
this population. However, negative effects on cognition, and in particular on
verbal fluency, have been reported following DBS. It is unclear, however, how
this decline relates to decline in language functioning and everyday
communication, jeopardising the quality of the information given to patients in
the decision-making process and after the surgical intervention.
Study objective
The present study aims at examining the effects of DBS on speaking. We will
test participants performing a verbal fluency task but also producing
spontaneous language and performing a language task that is dependent on a
brain area targeted by DBS.
Study design
We will compare PD patients in ON and OFF medication and stimulation conditions
with healthy matched controls and PD patients not candidate for DBS 6 months
after surgery.
Study burden and risks
For the control groups, no risks are present and the burden for participation
is low. For the DBS group: Medication and stimulation withdrawal themselves do
not pose any risk, if appropriate precautions are taken. However, the
withdrawal may cause discomfort to patients. There is a moderate chance of a
moderate risk in the OFF conditions (e.g., patients may fall). The novel
insights will broaden our understanding of the effects of DBS on speaking and
will help improve patient counselling
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
* Between 45 * 75 years of age
* Diagnosis of idiopathic Parkinson*s disease
* Native speaker of Dutch
* Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements
Exclusion criteria
* Dementia
* Psychiatric condition
* Other neurological condition known to influence language and cognition
* Hearing or visual impairment
* History of neurodevelopmental language disorders (i.e., dyslexia, specific language impairment).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL68706.091.19 |