Effects of NMES on physical function and skeletal muscle mass
ID
Source
Brief title
NMESSARC
Condition
- Protein and amino acid metabolism disorders NEC
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Chair stand test timed
Secondary outcome
Knee extension strength measured with a handheld dynamometer (MicroFet-2)
Skeletal muscle mass with bio-impedance analysis (Maltron Bioscan-II)
Background summary
Aging is associated with loss of skeletal muscle mass and strength, called
sarcopenia. Sarcopenia is highly prevalent in hospitalized geriatric patients.
It is probably one of the most important causes of functional decline in
acutely ill hospitalized geriatric patients. Resistant training is the best
therapy to counteract sarcopenia, however geriatric patients are not able to
perform this resistance training. Neuromuscular electro stimulation (NMES)
could be an alternative way to counteract the negative effects of sarcopenia.
In a previous pilot study feasibility was demonstrated.
Study objective
Effects of NMES on physical function and skeletal muscle mass
Study design
Prospective randomised intervention study. Patients will be randomised in two
groups: control group (CG) of 30 patients and an intervention group (IG) of 30
patients. The patients in the CG get usual care including physical therapy and
patients in the IG get on top neuromuscular electro stimulation (NMES) during
60 minutes a day during working week days. At baseline and at the end of the
study physical function is assessed with chair stand test (CST), skeletal
muscle strength of the upper legs with a handheld dynamometer (MicroFet-2) and
skeletal muscle mass with bio-impedance analysis (Maltron Bioscan-II). A
questionnaire is used to assess possible adverse events.
Intervention
The parients in the CG get usual care with daily physical therapy and the
patients in the IG get on top on work weekdays during 60 minutes a day NMES
(50Hz (10-100 Hz), 400 microsec (100-1000 ms), duty cycle 33% (0-100%)) of the
quadriceps muscle on both legs with an amplitude which results in visible
muscle contractions. These have to be tolerated by the patients.
Study burden and risks
Serious adverse events are not expected. Temporarily muscle strain, fatigue and
skin rash are possible side effects of NMES. We expect an improvement of
physical functioning with a better chair rise, improvement of strength of the
quadriceps muscles and finally counteract of skeletal muscle mass.
Dr. H. Van der Hoffplein 1
Sittard-Geleen 6162BG
NL
Dr. H. Van der Hoffplein 1
Sittard-Geleen 6162BG
NL
Listed location countries
Age
Inclusion criteria
Geriatric patients with sarcopenia according EWGSOP-2 criteria admitted to the
acute care geriatric ward
Inclusion and first measurement within the first three days after
hospitalization
Exclusion criteria
Inability to walk prior index disease/ hospitalization
Terminal condition eg due to metastatic cancer
Inability to walk due to pain of parese
ICD
No informed consent
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71911.096.19 |