The main objective is to collect hair samples from healthy participants, predilection and distant non-involved body sites of healthy subjects and from HS patients, for next generation sequencing and gene expression profiling, which will allow a wide…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
De proefpersonen fungeren als de controle groep van patienten met de huidziekte, dit betreft gezonde haren vanuit huid van gezonde proefpersonen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the difference of the HS immune response, inclusive
antimicrobial peptides, in relation to its microbiome compared to that of
healthy individuals.
Secondary outcome
Differences in microbiome composition between healthy controls and patients
with HS.
Background summary
HS is considered a complex disease involving different risk factors such as
lifestyle and environmental factors, as well as genetic factors. The clinical
presentation is reminiscent of bacterial infection. However, the structure of
the bacterial population, as well as the diversity at the strain level, is
poorly understood.
Study objective
The main objective is to collect hair samples from healthy participants,
predilection and distant non-involved body sites of healthy subjects and from
HS patients, for next generation sequencing and gene expression profiling,
which will allow a wide range of research questions related to hair follicle
steady state microbiology, immunology and pathology of HS patients relative to
healthy controls.
Study design
An explorative and experimental study design.
Study burden and risks
The healthy subject will not directly benefit from this research, but
participation contributes to increasing knowledge about HS and subsequently
improving treatment and care.
Dr. Molewaterplein 40 Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Dr. Molewaterplein 40 Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
1. Age * 18 years
2. Not suffering from hidradenitis suppurativa
3. Competent and willing to provide informed consent
Exclusion criteria
1. Age < 18 years
2. Use of systemic and local antibiotics in the past 2 weeks
3. Use of any other medication potentially affecting the follicular microbiome
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL69844.078.19 |