Smart device for clinically validated MOVEment assessment and monitoring at home and in the clinic (SMOVE)
PART 1: Feasibility and exploratory study in healthy adults

Monitoring and quantifying the physical activity and their intensity patterns
gives general insight into the intensity and type of activity people perform.
The qualitative aspects of movements (how are movements performed) can provide
detailed knowledge of specific biomarkers related to motor impairments. These
assessments are typically done in the controlled environment of the lab or
clinic. However, laboratory based analysis may not fully reflect individual
free-living motor capabilities while monitoring people in their home
environment, can provide more valid information about a person*s functioning,
and allows monitoring of interventions outside the clinic.
Wearable sensors, like (3D) accelerometers, gyroscopes and surface
electromyography make home monitoring possible. In the SMOVE project (Smart
device for clinically validated MOVEment assessment and monitoring at home and
in the clinic; INTERREG EU financed),
we aim to develop a *hybrid sensor system* for automatic, continuous
monitoring of specific movement features in the laboratory and especially in
free living-like conditions. In the present study we will first examine the
feasibility and test algorithms in a healthy population before examining
patient groups in the future.

The primary objective in the first phase is to test the feasibility of
recording hybrid IMU/EMG based movement/muscle activity parameters during
different movements in the lab and at home.
The primary objectives in the second exploratory phase are 1) to apply and
assess the performance of *best evidence* algorithms to automatically analyse
quantitative and qualitative aspects of movement in a supervised laboratory
setting (*living lab*), and 2) to test and when necessary adjust the above
laboratory based algorithms in the unsupervised free-living (@home) situation.

The secondary objectives in the second exploratory phase are 1) to determine
differences in biomarkers of movement between the young and old groups as part
of the performance assessment process, 2) to determine the added value of
EMG-based compared to IMU-based biomarkers to determine quantity and quality of
movement, 3) to determine the added value of using gyroscopes in comparison to
only accelerometers to determine quantity and quality of movement, 4) to
determine the added value of a heart rate measurement using an
electrocardiogram (ECG) sensor to determine intensity of movement, 5) to
determine the minimal number of sensors needed to extract the most important
movement biomarkers for the primary objectives, and 6) to determine the
test-retest reliability of those movement biomarkers for which no reliability
information is available from the literature.

Cross-sectional, observational study. Assessment of different types of movement
in the laboratory and in the free living situation (@home). Participants will
wear a portable device that allows hybrid EMG, ECG and accelerometry
measurements (SAGA from tMSI, Enschede, the Netherlands).

There are no risks or benefits, and the burden is limited to the time invested
in the test (approximately 2 hours in the lab, with breaks, and 8 hours of
observation at home). Video will be recorded of the participants throughout the
experiment, which will be anonymized in the post-processing.