To get insights into how the composition of the meal can affect the effects of prolonged sitting and sitting interrupted with physical activity on cognitive function and other health outcomes.
ID
Source
Brief title
Condition
- Lifestyle issues
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cognitive function
Secondary outcome
1) Cerebrovascular health
2) Metabolic health
3) Perceivable benefits
Background summary
Sedentary behaviour is an independent risk factor for cardiovascular disease,
type II diabetes and all-cause mortality and has also been related to impaired
cognitive function. In society today, often unhealthy meals are consumed (e.g.
high fat/high calorie) followed by prolonged periods of sitting. Resultantly,
people are exposed to the negative effects of sitting and of the meal. Much
research has been done to determine if reducing sitting can improve metabolic
health and results suggest that breaking up sitting with low-intensity or
moderate physical activity can modulate cardiovascular risk factors. However,
less is known about how a meal could interfere with the acute effects of
sitting and/or breaking up sitting on cardiovascular and cognitive health. Yet
it is known that one meal can acutely affect cognitive function and that the
meal composition influences the outcome.
Study objective
To get insights into how the composition of the meal can affect the effects of
prolonged sitting and sitting interrupted with physical activity on cognitive
function and other health outcomes.
Study design
Cross-over design
Intervention
On the assessment days participants will receive a breakfast of a specific
composition after which they will be required to either sit for four
consecutive hours or to sit interrupted with physical activity bouts.
Study burden and risks
Participants will visit the research center five times for a total of 28.5
hours. All measurements are non-invasive, except for the drawing of venous
blood. Venous blood sampling only poses a low risk. Short discomfort (3
minutes) is expected during emersion of the hand in ice-cold water during the
Cold Pressure Test (to measure vascular function). If the discomfort is
experienced as unbearable by a participant the test will be stopped. Together,
the nature and extent of the burden and risks associated with participation
have been evaluated as negligible. Yet, the study could give insight into
improving health in a large part of the general population which is at risk for
adverse health outcomes.
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
* Overweight or obese (BMI * 25 kg/m2 * 35 kg/m2)
* Sedentary and physically inactive (sitting > 40 hours per workweek; not meeting recommended aerobic physical activity levels of the WHO)
* Age * 45 years
* Ability to give informed consent
* Proficiency of the Dutch language
Exclusion criteria
Dietary habits/conditions that interfere with diet intervention, including following of a vegetarian diet
physical/mental conditions that interfere with diet/ physical activity intervention
MoCA score * 25
Diabetes mellitus, cardiovascular disease, gastrointestinal disease, cancer, epilepsy, unstable and/or untreated thyroid disease, untreated hypertension, major chronic disease or injury
Glucose/lipid lowering medication, anti-inflammatory medication, anti-depressant use with depression symptoms
Smoking, more than three alcohol consumptions per day
Currently participating in other research
Pregnant or lactating women, planned pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL64153.091.17 |
| OMON | NL-OMON25025 |