• To measure the quality of the red blood cells of redon drain blood before and after cell saver processing.• To measure the effects on whole redon drain blood in terms of inflammatory activation, platelet activation and blood rheology in the…
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Blood rheology
Secondary outcome
Blood gas parameters
Baseline platelet activation and activation triggered by a receptor activator
Inflammatory markers: Interleukin -6 (CXCL6), Interleukin -8 (CXCL8) and tumor
necrosis factor-α (TNF-α)
Hemolysis index
Background summary
In order to minimize the need for allogenic blood transfusion it is desirable
to auto-transfuse as much of the patients own blood as possible. In coronary
artery bypass grafting (CABG) the saphenous vein from the leg is routinely used
as graft material. It is currently unknown to what extend the immune- and
coagulation systems are activated and adequate blood rheology is maintained in
redon drain blood over time. It is also unclear to what extend this affects the
quality of the red bloods cells after cell saver processing. Therefore the aim
of this research is to measure the activation of the immune- and coagulation
system as well as determining the rheological properties of the RBCs in the
redon drain during the surgery and after cell saver processing.
Study objective
• To measure the quality of the red blood cells of redon drain blood before and
after cell saver processing.
• To measure the effects on whole redon drain blood in terms of inflammatory
activation, platelet activation and blood rheology in the patient before and
after the surgical procedure and in the redon drain before and after cell saver
processingat various time points intraoperatively.
Study design
The study will be a prospective repeated measures pilot study in the UMCG.
Study burden and risks
There is no strain on the participating patient during the research. The
patient is under anesthesia and only a very small blood sample of 10 ml in
total is collected. There will be no changes to the standard care for the
participants. All blood collection and processing will be carried out by well
trained personnel that is used to working in the OR environment. Therefore
there is no foreseeable risk involved with participation in this study.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
Scheduled for elective CABG with the use of saphenous vein graft material
Age >=18 years
Capable of understanding and speaking Dutch.
Exclusion criteria
Hematologic disorders
Sepsis
Unable to correctly understand the research by means of different langue
barrier or mental impairment
Less than 50 ml of blood has been collected in the redon drain at the end of
the surgery
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71988.042.19 |