The present fMRI study aims to investigate the effect of cognitive load on the neural processing of sweet and sour tastes. In particular, the aim is to disentangle the effects of cognitive load on the perceived intensity and hedonic value of taste…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
normaal functioneren van smaakverwerking in de hersenen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Neural activation as measured by fMRI and perceived taste intensity and hedonic
value in response to tasting sweet and sour solutions under high and low
cognitive load.
Secondary outcome
Performance on the Stroop task (to measure attentional control), BMI, responses
on the mobile Approach-Avoidance task (AAT) to measure food approach motivation
Background summary
People pay less and less attention to their meals, often engaging in other
activities simultaneously. Since mental capacity is limited, this leaves less
room for processing of sensory information such as taste. In this ongoing
research program, we test the hypothesis that mental load, induced by
concurrent tasks or concerns, interferes with reward processing from
consumption. Because people strive to obtain pleasure from the goods they
consume, they may overconsume to up-regulate hedonic value. Overconsumption is
the main driver of overweight and obesity.
Study objective
The present fMRI study aims to investigate the effect of cognitive load on the
neural processing of sweet and sour tastes. In particular, the aim is to
disentangle the effects of cognitive load on the perceived intensity and
hedonic value of taste stimuli. Furthermore, we aim to examine individual
differences of this effect related to BMI and attentional control capacity and
explore how these differences relate to real life food motivations.
Study design
Observational study consisting of one lab visit including an fMRI session and a
five-day follow-up by means of short questions and tasks on a mobile app.
Study burden and risks
This type of paradigm poses no significant risk. Participants will have a
70-min MRI scan during which they will perform a taste task. Functional MRI is
a commonly used technique which is considered to be safe when following
standard neuroimaging regulations. Additionally, measurements will be done to
assess relevant subject characteristics. In summary, the risk associated with
participation is assessed as low and the burden as minimal.
Wassenaarseweg 52 100
Leiden 2333AK
NL
Wassenaarseweg 52 100
Leiden 2333AK
NL
Listed location countries
Age
Inclusion criteria
• Healthy (self-reported)
• Right-handed
• Between 18 and 45 years old.
• Having given their written informed consent
• BMI between 18.5-30 kg/m2
Exclusion criteria
• Having a history of or current alcohol consumption > 28 units per week
• Daily smoking
• Suffering from cold symptoms
• Having a history of medical or surgical events that may significantly affect
the study
outcome, such as metabolic or endocrine disease, or any gastro-intestinal
disorder
• Mental or physical status that is incompatible with the proper conduct of the
study
• Not having a general practitioner
• Participation in any other clinical trial during this study.
• Common MRI exclusion criteria, including
o Claustrophobia
o Presence of metal in body incompatible with MRI scanning
o Pacemaker
o Being pregnant.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72215.058.19 |