The primary objective of this feasibility study is to investigate if biomarkers for oxidative stress in blood and urine increase after a short (
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
patienten met aandoeningen waarvoor zuurstof therapie noodzakelijk is voor of bij binnenkomst op de SEH
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The variation in FiO2, PaO2, SpO2 and levels of oxidative stress among patients
with an infection admitted to the ED who receive oxygen therapy.
Secondary outcome
- The correlation between baseline PaO2 and levels of oxidative stress in blood
and urine in non-trauma
ED patients receiving oxygen therapy;
- To investigate if dynamic changes in PaO2 over time are related to changes in
biomarkers of oxidative stress.
Background summary
Much is known about the harmfull effects of hypoxia. For this reason, oxygen
therapy is given to acutely ill patients easily. Howeverm the last few years
more and more is known about the detrimental effects of hyperoxia. Patient who
receive too much oxygen for a longer period of time (>24 hours) have shown to
have increased comorbidities and even higher mortality rates. It is yet unknown
of these detrimental effects of hyperoxia are also apparant after a short
period of time (within 1 hour). Since the ED is the designated plase to start
oxygen therapy, it is important to investigate is we should be cautious about
these detrimental effects of a short period of hyperoxia as well. One way to
investigate these effects is to look at the occurence of oxidative stress
biomarkers in blood and urine samples. It is also yet unknown if these
biomarkers occur after a short period of time.
Study objective
The primary objective of this feasibility study is to investigate if biomarkers
for oxidative stress in blood and urine increase after a short (<1 hr) period
of oxygen supplementation, and if so, whether these are related to paO2 levels.
Study design
This is a single centre prospective cohort study.
Study burden and risks
Since care will be provided as usual and extra blood and urine samples (in
small amounts) will only be obtained at moment when samples will normally also
be obtained, the risks and burden will be small for patients.
Hanzeplein 1
Groningen 9713GZ
NL
Hanzeplein 1
Groningen 9713GZ
NL
Listed location countries
Age
Inclusion criteria
- Non-trauma patients presenting to the ED who already receive oxygen therapy
started by EMS or in whom oxygen therapy is started in the ED an in whom an
infection is suspected
- Adult (i.e. age > 18 years)
- Able to provide (deferred) informed consent themselves or informed consent
can be obtained via next of kin or legal gardian
Exclusion criteria
- SpO2 < 94% or PaO2 < 9.5 kPa despite oxygen therapy
- Chronic Obstructive Pulmonary Syndrome (COPD) Gold III or IV
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71979.042.19 |