a) To determine the occurrence of subclinical and clinical disease and transmission of SARS-CoV-2 in families with children aged 14-18 years; and b) to examine the associations of socio-demographic and lifestyle, genetic, and epigenetic factors with…
ID
Source
Brief title
Condition
- Viral infectious disorders
- Respiratory tract infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
SARS-CoV-2 symptoms, infection, severity of disease and transmission, and
environmental and genetic risk factors for (sub-)clinical disease and disease
severity.
Secondary outcome
NA
Background summary
The SARS-CoV-2 pandemic is a threat to the health and wellbeing of children and
parents. The causes and contributing factors to this are unknown, as is the
role of asymptomatic and symptomatic children in the spread of the virus and
the development of herd immunity. The Ministry of Health, Welfare and Sport and
ZonMw have approached a number of research groups to help answer questions
related to the spread and transmission of the virus in specific groups. The
UMCU/Spaarne Gasthuis and Erasmus MC in collaboration with the RIVM will study
children in various age ranges, who are participating in ongoing cohort
studies, to examine carriership and transmission in children and families.
Given the impact and relevance of findings for public health decisions and the
funding that Generation R receives from the Ministry, we would like to
contribute. Due to its prospective, longitudinal and detailed data collection
in a large population and its existing infrastructure, the Generation R Study
represents an excellent basis for studies into transmission and risk factors of
SARS-CoV-2 in children and their families.
Study objective
a) To determine the occurrence of subclinical and clinical disease and
transmission of SARS-CoV-2 in families with children aged 14-18 years; and b)
to examine the associations of socio-demographic and lifestyle, genetic, and
epigenetic factors with subclinical and clinical disease, and transmission of
SARS-CoV-2 within households.
Study design
The project will be embedded in the Generation R Study, a population-based
prospective study from early pregnancy onwards. A total of 9,778 pregnant women
were includes between 2002 and 2006 in Rotterdam. The women, their partners and
children are being prospectively followed since then. Detailed data have been
collected on the participants in multiple follow-up rounds
Study burden and risks
Participation poses minimal risk only. Data are collected through digital
questionnaires, an existing app, and by collection of respiratory swabs,
saliva, and capillary blood sampling, which may cause transient discomfort and
rarely infection. Participants may see their participation as a valuable
contribution to science and potentially to society, but the direct personal
benefits of participation are limited.
Dr Molenwaterplein 50
Rotterdam 3015 GE
NL
Dr Molenwaterplein 50
Rotterdam 3015 GE
NL
Listed location countries
Age
Inclusion criteria
- Participation in the Generation R Study *Focus Cohort*
- Consent to be approached for additional studies as indicated in the most
recent informed consent form
- Household family members of the participant in the Generation R Study *Focus
Cohort* with consent to be approached for additional studies as indicated in
the most recent informed consent form
Exclusion criteria
- None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74709.078.20 |