Does performance on a fatiguing dual task task in patients with FSM decline more compared to patients with AIS? What are the differences in cognitive functioning and motor fatigue between FSM, AIS and healthy controls? What is the relation between…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Performance on the two-choice reaction time task (CRT): reaction times, and
number of errors; during and after the fatiguing motor task.
Secondary outcome
- Anxiety and Depression scores (HADS)
- Fatigue questionnaire scores (DMFS, FSS, MFIS)
- Side strongest hand
- Difference stimulated maximum force and voluntarily delivered maximum
force.
- Baseline characteristic; sex and age.
Background summary
In functional neurologic disorders the function of the nervous system is
disturbed without structural damage. Patients with functional disorders can
present with acute stroke-like symptoms, this is called a functional stroke
mimic (FSM). Fatigue is a major problem in functional neurologic disorders and
in acute ischemic stroke (AIS). In this study we want to gain more insight into
the interaction between motor and cognitive fatigue. Studies in healthy
controls have shown that during a dual-task (DT), a cognitive task combined
with a fatiguing motor task, the performance on a cognitive task declines over
time (with fatigue). We hypothesise that in patients with a functional stroke
mimic and patients with AIS this interaction is stronger compared to healthy
controls. We also want to study whether the symptoms and the interaction
between cognitive and motor fatigue recover with time. Our group has already
performed this dual-task in patients with MS. (METc 2010-150)
Study objective
Does performance on a fatiguing dual task task in patients with FSM decline
more compared to patients with AIS? What are the differences in cognitive
functioning and motor fatigue between FSM, AIS and healthy controls? What is
the relation between fatigue questionnaire scores and performance on the
cognitive and motor tasks? How does the performance on the dual-task change
after a year in FSM and AIS?
Study design
The study design is a mono-centre intervention study. Subjects perform a
cognitive task: a two choice reaction time task (CRT). The CRT is performed on
its own, and simultaneously with a motor task (i.e. the dual-task). Patients
and controls will be measured at two time points, 6 weeks and 12 months after
admission to the hospital. At each time point the investigation comprises two
sessions of one and a half hour, on two separate days. Force and muscle
activity (EMG) of the first dorsal interosseous muscle (FDI) are measured
during every session. During the force measurement the ulnar nerve will be
stimulated electrically. The maximal sqeeze force will be measured in both
hands using a sqeeze force gauge.
Intervention
nvt
Study burden and risks
There are no risks involved. Time investment for subjects is 2 x 2 x 1.5 hours
(6 hours).
Hanzeplein 1
Groningen 9700 RB
NL
Hanzeplein 1
Groningen 9700 RB
NL
Listed location countries
Age
Inclusion criteria
* Age: 18-67 years
* For patients: Diagnosis of functional stroke mimic or AIS
* In patients with AIS: NIHSS <10 at presentation.
* Good hand-function
* Right-handedness
Exclusion criteria
* Drugs or alcohol addiction
* Psychiatric disorder
* Neurologic disorder other than FSM or AIS
* Impaired hearing
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72758.042.20 |