The objective of this study is:- to estimate the electrical conductivity of the chronic stroke lesion and the variance on this within chronic stroke subjectsSecondary:- derive functional organisation of the motor system of the upper extremity…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Electrical conductivity of the lesion, estimated per individual patient
Secondary outcome
- Functional motor area, estimated per individual
Background summary
Motor impairments are frequent after stroke. Transcranial direct current
stimulation is a way that could possibly improve motor rehabilitation after
stroke. In clinical studies with stroke patients, mixed results are found,
however, possibly due to a one-fits-all approach which is not valid for stroke
patients. Dependent on the lesion location and size and the functional
reorganisation, the brain stimulation has to be applied differently. At the
moment it is not clear from literature what the influence of the lesion is on
the electric field that is generated by the brain stimulation. To improve brain
stimulation, more knowledge on this is required.
Study objective
The objective of this study is:
- to estimate the electrical conductivity of the chronic stroke lesion and the
variance on this within chronic stroke subjects
Secondary:
- derive functional organisation of the motor system of the upper extremity
through EEG, using fMRI as a reference
Het doel van dit onderzoek is:
- te bepalen wat de elektrische geleidbaarheid van de laesie is en wat de
variabiliteit hierop is binnen chronsiche cva patiënten
Secundair:
- het middels EEG bepalen van de functionele organisatie van het motorisch
systeem van de bovenste extremiteit, met fMRI als referentie
Study design
Observational, exploratory study
Study burden and risks
Low risk: the MRI, as well as the tDCS, EEG and the motor tasks form no risks
on the health of the participant.
The MRI will be recorded by the radiology department of Erasmus MC. All
recordings will be performed according to existing protocols.
The tDCS will be applied on subclinical intensity, such that participants will
unlikely notice anything from the stimulation. The application of tDCS on
clinical intensity has been verified to be safe and of negligible risk.
EEG is a safe, non-invasive form to measure brain signals
The burden for participants is a time investment of 4 hours in total, divided
over 2 sessions (1 hour for the first session, 3 hours for the second session)
Due to the low burden and low risk of the study, we think performing this study
is justified.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
- Capable to perform a simple motor task with the hand
For the stroke patients:
- Ischemic stroke at least 6 months before the experiment starts
- Reduced (but not absent) motor function
Exclusion criteria
- Implants or metal parts in head/body
- Usage of medication or drugs that affect the nervous system
- Pregnancy
- Not capable to perform a simple motor task
- Unable to understand the instructions
- Epilepsy
- Alcoholism
- Cognitive impairment or (history of) psychiatric disorders
- Hemineglect
- Claustrophobia
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL70630.078.19 |