Research with human participants

Overview of medical research in the Netherlands

IgG and IgA response to SARS-CoV-2 in serum and saliva samples from infected healthcare workers who suffered from relatively mild disease

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Last updated:

To investigate the dynamics of IgA and IgG antibody level against SARS-CoV-2 in 86 health care workers with relatively mild symptoms.

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Ethical review
Approved WMO
Status
Pending
Health condition type
Viral infectious disorders
Study type
Observational invasive

ID

NL-OMON49759

Source

ToetsingOnline

Brief title

Investigation into the antibody response to SARS-CoV-2 infection

Condition

  • Viral infectious disorders
  • Respiratory tract infections

Synonym

COVID-19, new coronavirus

Research involving

Human

Sponsors and support

Primary sponsor :
Elisabeth-Tweesteden ziekenhuis
Source(s) of monetary or material Support :
Ministerie van OC&W

Intervention

Keyword :
Antibody response, IgA, IgG, SARS-CoV-2

Outcome measures

Primary outcome

IgG and IgA titers

Secondary outcome

sensitivity of Euroimmun assay, the presence of virus neutralizing antibodies

Background summary

Refer to pag 1 of study protocol

Study objective

To investigate the dynamics of IgA and IgG antibody level against SARS-CoV-2 in
86 health care workers with relatively mild symptoms.

Study design

Observational study

Study burden and risks

4 x venapuncture (6 ml); pain and brusing.
4 x saliva sample; possible irritation of gum

Public
Elisabeth-Tweesteden ziekenhuis

Hilvarenbeekseweg 60
Tilburg 5022 GC
NL
Scientific
Elisabeth-Tweesteden ziekenhuis

Hilvarenbeekseweg 60
Tilburg 5022 GC
NL

Listed location countries

Netherlands

Age

Adults (18-64 years)
Elderly (65 years and older)

Inclusion criteria

Healthcare workers with confirmed SARS-CoV-2 infection.

Exclusion criteria

unable to give written informed consent; health care workers that are involved
in the design and execution of this study.

Design

Study type :
Observational invasive
Masking :
Open (masking not used)
Control :
Uncontrolled
Primary purpose :
Diagnostic

Recruitment

NL
Recruitment status
:
Pending
Start date (anticipated) :
Enrollment :
86
Type :
Anticipated

Approved WMO
Date :
Application type :
First submission
Review commission :
METC Brabant (Tilburg)
Approved WMO
Date :
Application type :
Amendment
Review commission :
METC Brabant (Tilburg)

Followed up by the following (possibly more current) registration

No registrations found.

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
CCMO NL73713.028.20