The primary objectives are to study short-term changes in lung function, respiratory symptoms, bronchodilator medication use, and stress in association with short-term changes in woodsmoke exposures in adults suffering from asthma/COPD and healthy…
ID
Source
Brief title
Condition
- Other condition
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Health condition
Stress ten gevolge van houtrook
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoints are lung function (FEV1 and PEF), daily respiratory
symptoms, use of bronchodilator medication, and cortisol.
Secondary outcome
Secondary parameters include inflammatory markers Interleukin (IL) 1b, IL-6,
IL-8, IL-10, and tumour necrosis factor (TNF)*.
Background summary
The Netherlands has about one million active woodstoves and fireplaces emitting
a substantial amount of woodsmoke. Woodsmoke has become a regular nuisance for
about 10% of the general Dutch population and 64% for the Dutch asthma and
COPD patient population. There are still considerable knowledge gaps in the
scientific literature about the level of woodsmoke exposure and related health
effects in the Netherlands. This project will investigate the health effects of
short-term exposure to woodsmoke in different areas in the Netherlands. This
research question was chosen after consulting with citizens, organized
stakeholders, experts and previous academic literature. This project will take
on a co-created citizen science approach.
Study objective
The primary objectives are to study short-term changes in lung function,
respiratory symptoms, bronchodilator medication use, and stress in association
with short-term changes in woodsmoke exposures in adults suffering from
asthma/COPD and healthy adults. As a secondary objective we will also study the
short-term changes in inflammatory markers in association with short-term
changes in woodsmoke in the panel groups.
Study design
Panel study with repeated observations of respiratory health, cortisol and
inflammatory markers in two panels of adults diagnosed with asthma/COPD and
healthy adults over a three month period. Participants from both panels will
complete daily symptom reporting and home spirometry, provide weekly cortisol
samples and three inflammatory marker samples.
Study burden and risks
Total participation time for a participant in the study is three months. Each
participant will fill in a daily diary which takes 3 minutes at most. Twice
daily participants will conduct a simple lung function measurement of about 2
minutes. Participants will collect saliva samples once a week for cortisol
determination which takes about 15 minutes. Furthermore, participants will also
collect 3 nasal mucosal lining fluid samples which takes about 5 minutes per
sample. There is no risk involved in participating. Participants don*t directly
benefit from participating, unless significant associations are found causing
new policy measures to be taken to reduce woodsmoke emissions in their living
environment. If no associations are found this may reduce societal concern. In
our experience with past panel studies, participating for 3 months is
reasonable, people who start participating will almost always complete the
requested period. Each participant will be given a 25 euro gift card as a token
of our appreciation.
Yalelaan 2
Utrecht 3584CM
NL
Yalelaan 2
Utrecht 3584CM
NL
Listed location countries
Age
Inclusion criteria
Participant is 30 years or older
Participant lives in the participating study area
Participants for the asthma/COPD panel need to comply with the following
criteria:
o Self-reported doctors diagnosis of asthma/COPD.
o Report of wheezing, shortness of breath And/or use of asthma/COPD medication
in the past 12 months.
Participants for the healthy adult panel need to comply with the following
criteria:
o No self-report of a doctor diagnosis of asthma/COPD ever
o No report of wheezing, shortness of breath, chronic cough, phlegm in the past
12 months
o No use of asthma/COPD medication in the past 12 months
Exclusion criteria
Active smokers
Subjects with a wood stove or fireplace
People with absolute contra-indications for spirometry:
o Heart attack in the last three months
o Chest or abdominal surgery in the past 3 months
o A brain, ear or eye surgery in the past 1 month
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75223.041.20 |