10 years ago we selected an unique cohort of 154 patients with acute ACL injuries, who were prospectively characterized over the first two years post-injury. A single follow-up measure within this established cohort is proposed, to those that gave…
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Clinical knee osteoarthritis
Secondary outcome
Radiographic knee osteoarthritis and progression of structural osteoarthritis
features on MRI.
Background summary
Anterior cruciate ligament (ACL) rupture is a strong risk factor for knee
osteoarthritis. Unfortunately, there are no treatment options to prevent
osteoarthritis development in subjects with ACL rupture. Being able to predict
occurrence of osteoarthritis by relating early changes in symptoms and
structural features to long-term disease development, will enable the
identification of new treatment targets for orthopaedic surgeons that could
prevent future knee osteoarthritis development. Also, it will allow for the
identification of relevant subgroups of patients at high risk for future
osteoarthritis development that could serve as target population for future
trials.
Study objective
10 years ago we selected an unique cohort of 154 patients with acute ACL
injuries, who were prospectively characterized over the first two years
post-injury. A single follow-up measure within this established cohort is
proposed, to those that gave written consent (N=152). Questionnaires,
radiography and MRI will allow the evaluation of the natural course of
structural and symptomatic knee osteoarthritis development. This data will also
answer important questions like: Which group of patients are at increased risk
for osteoarthritis development? Which early changes in symptoms and/or
structures should be targeted to prevent osteoarthritis development?
Study design
Single observation extending the follow-up duration of a previously initiated
prospective cohort study.
Study burden and risks
Participating in this study requires minimal effort from participants (visit to
Erasmus MC, fill in the questionnaire, and undergo radiography, MRI and
physical examination) at negligible risk.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
- participated in the KNALL study
- written consent to be contacted for further research
Exclusion criteria
Not willing to participate
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL73540.078.20 |