To assess T cell activation in patients with extremely high Lp(a) levels versus controls with low Lp(a)
ID
Source
Brief title
Condition
- Coronary artery disorders
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will compare the phenotype, cytokine production and epigenetic
characteristics of T cells between patients with high and low Lp(a), with and
without a history of cardiovascular disease. Additionally, we will determine
the conditions under which healthy T cells are promoted to pro-inflammatory
phenotypes and evaluate the ex vivo reversibility of this phenotype.
Secondary outcome
NA
Background summary
Patients with high lipoprotein(a) (Lp[a]) levels are characterised by
accelerated atherosclerosis. However, the mechanisms underlying this increased
risk remain largely unknown. Recent data indicates that T cells form the
principal cell population in atherosclerotic plaque. As the atherosclerotic
burden associated with high Lp(a) is thought to derive more from inflammatory
signalling than from the sole accumulation of lipids, we hypothesise this
patient group in particular will be characterised by profound T cell activation
compared to controls with normal Lp(a) levels, both in subjects with and
without a history of cardiovascular disease (CVD).
Study objective
To assess T cell activation in patients with extremely high Lp(a) levels versus
controls with low Lp(a)
Study design
Observational case control study
Study burden and risks
Participants will fill out a questionnaire and blood will be withdrawn.
Volunteers from the high Lp(a) group could benefit from better insight into the
pathophysiological mechanisms mediating accelerated atherosclerosis, which
could lead to the development of novel therapies. Participants from the low
Lp(a) group have no benefit of participating in the study.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
1. High lipoprotein(a) with known cardiovascular disease
2. Low lipoprotein(a) with known cardiovascular disease
3. High lipoprotein(a) without known cardiovascular disease
4. Low lipoprotein(a) without known cardiovascular disease
Exclusion criteria
- HIV
- Chronic kidney disease
- Any condition which could possibly interfere with the conduction or outcome
of the study to the opinion of the investigator
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL73695.018.20 |