To investigate brain morphology and brain activation in response to odor stimulation in participants with a normal smelling ability.
ID
Source
Brief title
Condition
- Other condition
- Central nervous system infections and inflammations
Synonym
Health condition
reukvermogen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) volume of olfaction-related brain areas; 2) activation of brain areas during
odor stimulation compared to the control condition.
Secondary outcome
1) olfactory function and its relation with the primary study parameters; 2)
activation of functional brain networks
Background summary
Olfaction is important in daily life. While olfactory loss is not often
discussed, 3 to 20% of the general population is affected by olfactory loss.
Previous studies showed that olfactory loss can affect both brain morphology of
olfaction-related areas and brain response to odor stimulation within patients.
To better understand how olfactory loss affects the processing of odors in the
brain, we need more knowledge on how odors are processed in the brain of
individuals with a normal sense of smell.
Study objective
To investigate brain morphology and brain activation in response to odor
stimulation in participants with a normal smelling ability.
Study design
This is an observational study in healthy participants. For all participants,
two visits will be planned. During a training session (1h) at Wageningen
University, Wageningen, an olfactory and taste test will be performed (40
minutes). Participants who pass the olfactory test will be familiarized with
the test situation that will be used during the study day (20 minutes) using a
dummy MRI scanner. The study day (1.5h) includes a visit to the MRI facilities
in Hospital Gelderse Vallei, Ede. Participants fill in a safety questionnaire
and a demographics questionnaire (10 minutes), and undergo an MRI measurement
(60 minutes). The MRI measurement consists of two subparts: anatomical imaging
of the brain (~20 minutes) and a functional session including a paradigm during
which subjects are presented with odors (~30 minutes).
Study burden and risks
The study is non-therapeutic to the subjects. No immediate benefits for the
subjects are expected from participation in this study. The risk associated
with participation is negligible. The subjects* burden is as follows, regarding
time: the training session will take approximately 1h; the experimental session
will take approximately 1.5h, including one hour inside the MRI scanner. MRI is
an eminently safe technique; there are no risks that have been associated with
the acquisition of MRI data per se. The MRI-scans in this study are not made
with the intention to diagnose pathologies, however, chance findings of
pathology may occur. Participants will be informed of this possibility and need
to be willing to receive information about incidental findings of pathology.
Participants can leave the study at any time for any reason if they wish to do
so without any consequences.
Stippeneng 4
Wageningen 6708 WE
NL
Stippeneng 4
Wageningen 6708 WE
NL
Listed location countries
Age
Inclusion criteria
Self-reported healthy
No known smell disorder
No history of head trauma
No neurological disorders (like Alzheimer*s or Parkinson*s disease)
Labelled as having a normal sense of smell according to our standardized
clinical olfactory test Sniffin* Sticks) (score >= 30.5 points out of 48 points)
Age between 18-75 years
Have normal eyesight or an eye deviation that can be corrected with glasses or
contact lenses.
Willing to comply with the study procedures
Willing to be informed about incidental findings of pathology and approving of
reporting this to their general physician
Having given written informed consent (see E1.Informatiebrochure)
Exclusion criteria
Having a contra-indication to MRI scanning (including, but not limited to):
o Being pregnant
o Pacemakers and defibrillators
o Intraorbital or intraocular metallic fragments
o Ferromagnetic implants
o Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL78132.091.21 |