• 1A: Does aging have additional effects on motor performance in persons with MS compared to age- and sex matched controls?• 1B: Does aging have additional effects on fatigue and fatigability in persons with MS compared to age- and sex matched…
ID
Source
Brief title
Condition
- Demyelinating disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in persons with MS and in controls over three time points (present
time, after 5 and after 10 years) in:
a) the number of pins placed in a Purdue pegboard task;
b) maximal handgrip and index finger abduction force and
c) the decline in force over a 2-minute sustained maximal contraction.
d) the number of correct digits in the symbol digit modality test.
Secondary outcome
not applicable
Background summary
Multiple sclerosis (MS) is a chronic demyelinating disease which presents
itself with acute inflammatory episodes and co-occurring neurodegeneration. The
neuropathological processes are linked to progression in physical disability,
cognitive performance and sense of fatigue. New disease modifying therapies
increase the mortality prognosis and raises questions on the effects of aging
on these parameters.
Study objective
• 1A: Does aging have additional effects on motor performance in persons with
MS compared to age- and sex matched controls?
• 1B: Does aging have additional effects on fatigue and fatigability in persons
with MS compared to age- and sex matched controls?
• 1C: Does aging have additional effects on cognitive performance in persons
with MS compared to age- and sex matched controls?
Study design
Observational longitudinal case-controlled study.
Study burden and risks
Participants perform the tasks (3 times 1 hours) at the UMCG. No risks are
associated with experimental protocol. The results contribute knowledge on the
effect of aging on MS-related symptoms.
Hanzeplein 1
Groningen 9700AV
NL
Hanzeplein 1
Groningen 9700AV
NL
Listed location countries
Age
Inclusion criteria
• Diagnosed with Multiple sclerosis
• Being able to hold the force transducer and Pegboard pins
Exclusion criteria
• Neurological or muscle disorders other than MS
• Other conditions affecting fatigue
• Depressive symptoms
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL70927.042.19 |