To establish the relationship between past illness with SARS-CoV2 infection and endothelial dysfunction.To study the long-term effects of SARS-CoV2 on endothelial function.To explore the influence of Covid disease severity on the degree and duration…
ID
Source
Brief title
Condition
- Viral infectious disorders
- Vascular injuries
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endothelial dysfunction as determined by carotid artery reactivity (CAR) test
Secondary outcome
Major adverse cardiovascular events (MACE) within one year post-COVID-19 is an
exploratory endpoint. In this study, MACE include non-fatal myocardial
infarction, non-fatal ischemic stroke, acute limb ischemia, need for
revascularization, amputation and cardiovascular death.
Background summary
The coronavirus disease 2019 (COVID-19) may lead to vascular damage and
thrombotic events. A prevalence of arterial thromboembolism of 4% has been
described on the intensive care unit in the Netherlands . Presumably, incidence
of arterial thromboembolism is much higher because of long duration of
intensive care admission and high threshold to perform diagnostic imaging tests
because of strict isolation and often prone positioned patients. An explanation
for the influence of COVID-19 on arterial thromboembolic risk could be found on
the entrance site of the severe acure resiratory syndrome corona virus
(SARS-CoV) 2. SARS-CoV2 enters human cells through binding to ACE2 receptor on
the cell surface, enabling it to infect the cell. Equal to, and with similar
affinities, as SARS-CoV in 2002. Animal and in vivo studies demonstrate that
binding of SARS-CoV to ACE 2 receptor can down-regulate the expression of ACE 2
in the endothelial cells. ACE 2 protects the vascualr wall against inflammation
and atherosclerosis. Decreased ACE 2 expression in the vascular wall leads to
endothelial dysfunction, which is strongly related to the occurence of arterial
thrombotic events
Study objective
To establish the relationship between past illness with SARS-CoV2 infection and
endothelial dysfunction.
To study the long-term effects of SARS-CoV2 on endothelial function.
To explore the influence of Covid disease severity on the degree and duration
of endothelial dysfunction.
Study design
Prospective observational longitudinal cohort study.
Study burden and risks
For this study, participants will visit the hospital twice for carotid artery
reactivity (CAR) testing. During CAR test, participants are in the supine
position. Left carotid artery will be visualized by ultrasound during baseline
and during 3 minutes of hand immersion in icy water of 4°C. During hand
immersion in icy water the participant can experience short-during discomfort,
which will directly resolve after completion of the test and will cause no
further harm. No risks are involved with this study.
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
- Confirmed severe acute respiratory syndrome corona virus 2 (SARS-CoV2)
infection by polymerase chain reaction on nasopharyngeal swab, sputum or
bronchoalveolar lavage.
- 6 to 20 weeks after resolution of COVID-19 related symptoms
- >= 16 years old
Exclusion criteria
- Recent (<3 months) angina pectoris, myocardial infarction, stroke, or heart
failure
- Raynaud syndrome, scleroderma or complex regional pain syndrome on upper
extremity or presence of arteriovenous fistula or open wounds on both upper
extremities.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74101.091.20 |