To investigate protein synthesis rates and enrichments of femoral bone tissue proximal and distal to a hip fracture.
ID
Source
Brief title
Condition
- Other condition
- Fractures
Synonym
Health condition
Eiwitmetabolisme in verschillende musckuloskeletale weefsels
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome parameters are bone protein synthesis rates in the femoral
shaft and femoral head tissue, expressed in FSR (%/h).
Secondary outcome
The secondary outcome parameters are tissue-specific protein synthesis rates in
femoral bone, femoral head cartilage, hip synovium, and skeletal muscle,
expressed in FSR (%/h). In addition, plasma enrichments of
L-[ring-13C6]-phenylalanine is a secondary outcome parameter.
Background summary
Skeletal muscle plasticity is defined by a dynamic balance between protein
synthesis and protein breakdown rates. Recently, we have shown basal protein
synthesis rates in various musculoskeletal tissues of the knee joint, including
bone, cartilage, and tendon tissue. Interestingly, most of these tissues
possess protein synthesis rates within the same range of skeletal muscle
protein synthesis rates. However, it is not known whether the protein synthesis
rates of bone tissue change after a traumatic event (i.e. bone fracture). In
older adults, hip fractures are one of the most common fractures that require
surgical intervention. After a hip fracture, the vitality of the femoral head
is often reduced. It is not known whether osteonecrosis of the femoral head
happens due to reduced protein synthesis or extensive breakdown. Therefore,
this project will apply the stable isotope methodology to measure
tissue-specific protein synthesis rates in fractured femoral bone.
Study objective
To investigate protein synthesis rates and enrichments of femoral bone tissue
proximal and distal to a hip fracture.
Study design
Prospective observational study.
Study burden and risks
The burden for participating patients is minimal.
The only additional actions that are required in addition to routine care are
the intravenous infusion of a stable isotope amino acid solution 2.5 h before
surgery untill the end of surgery and sampling of blood through a catheter. The
insertion of the catheter can cause a hematoma.
Universiteitssingel 50
Maastricht 6229 ER
NL
Universiteitssingel 50
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
1) Written informed consent;
2) Recent (<24 h before admission to the hospital) femoral bone fracture
requiring hip replacement surgery;
3) Admitted to MUMC+ to receive a femoral head-neck prosthesis or total hip
replacement.
Exclusion criteria
1) Physical restlessness due to delirium;
2) Rheumatoid arthritis;
3) Chemotherapy or radiotherapy;
4) (Multiple) Myeloma or other primary cancer tumor with possible bone
metastasis;
5) Collagen disorders, e.g. Marfan and Ehler-Danlos;
6) Any other medical condition that may interfere with the safety of the
subjects or the outcome parameters, in the investigators judgement;
7) Investigator*s uncertainty about the willingness or ability of the subject
to comply with the protocol instructions;
8) Participation in any other studies involving investigational or marketed
products concomitantly to entry into the study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75424.068.20 |
| Other | wordt geregistreerd na positief besluit |