We aim to (1) assess differences in cognitive performance between trans women (male assigned at birth with female gender identity), trans men (female assigned at birth with male gender identity), cis (non-trans) men, and cis women; (2) determine…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
patienten met genderdysforie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endpoints that are of particular interest to this study and have been studied
within the LASA framework include: general cognitive functioning (Mini-Mental
State Examination), coding task, 15-word test (immediate and delayed recall),
letter and category fluency, GIT, and number series (forward and backward). An
exhaustive list of items that are part of the general LASA data collection can
be found in Huisman et al (2011), and Hoogendijk et al. (2016), attached.
Secondary outcome
The following variables will be investigated as mediators: 1) psychological
factors including depressive symptoms (CES-D) and anxiety (HADS-A),
self-esteem/efficacy questionnaire, life satisfaction and (history of)
psychiatric/psychological help, and 2) social factors including loneliness (De
Jong-Gierveld & Kamphuis Loneliness Scale) and discrimination, and 3)
cardiovascular parameters including self-report on cardiovascular disease,
diabetes, stroke and high blood pressure, medication use, health-related
behaviour (smoking, alcohol consumption, sleep), BMI and blood pressure (2x).
In addition, the following demographic information will be gathered:
sex/gender, age, region in the Netherlands, marital status, housing,
spirituality, socioeconomic status, feelings of masculinity/femininity.
Information regarding contentment with medical treatment(s), body satisfaction,
and sexuality will be collected as well.
Background summary
The number of individuals seeking (medical) help for gender dysphoria has
strongly increased. Medical help may consist of gender-affirming hormone
therapy (GHT), which could potentially have beneficial effects on cognition.
However, increased cardiovascular risk (CVR) and psychological problems among
transgender individuals could negatively influence cognition. Long-term GHT
effects on cognition in the rising number of elderly transgender individuals
are unknown.
Study objective
We aim to (1) assess differences in cognitive performance between trans women
(male assigned at birth with female gender identity), trans men (female
assigned at birth with male gender identity), cis (non-trans) men, and cis
women; (2) determine whether differences in cognition could be explained by
differences in CVR and psychological factors between these groups.
Study design
Cross-sectional observational study.
Study burden and risks
The data collection encompasses a face-to-face interview, consisting of
validated questionnaires and including among others cognitive tests, and a
self-administered questionnaire. The interview takes about 1.5 hours. The
self-administered questionnaires are handed out by the interviewers and are
sent back in a stamped envelope by the respondents. Interviews take place at
the respondent*s home address.
Contents of the interview and questionnaire include aspects of physical,
emotional, social and cognitive functioning. We consider the most burdensome
aspects of the data collection the general cognitive functioning, because these
may be confronting to respondents. All data collection is completely
observational and non-invasive. In general, there are no risks associated with
participation in the study, but for frail older adults the data collection
might be more burdensome. If participants indicate that they feel it is too
burdensome beforehand, they will be excluded from the study.
De Boelelaan 1117
Amsterdam 1081HV
NL
De Boelelaan 1117
Amsterdam 1081HV
NL
Listed location countries
Age
Inclusion criteria
Age >55 years
Diagnosis of gender dysphoria
Continued and consistent use of GHT for at least 10 years
Currently in treatment at the Center of Expertise on Gender Dysphoria (i.e.,
last clinical appointment <2 years ago)
Exclusion criteria
No sufficient understanding of the Dutch language
Subjects that indicate on forehand to be too frail for full participation in
the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72669.029.20 |