The main goal of this study is to analyse the influence of the menstrual cycle on NK cell receptor variability.
ID
Source
Brief title
Condition
- Immunodeficiency syndromes
- Menstrual cycle and uterine bleeding disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Percentage of NK cells with activating and inhibitory receptors in peripheral
blood.
Secondary outcome
Percentage of NK cells with activating and inhibitory receptors in menstrual
blood.
Percentage of degranulation of NK cells in peripheral blood.
Percentage of degranulation of NK cells in menstrual blood.
Background summary
The human menstrual cycle is a complex physiological process with profound
effects on many organs and systems in the body including the immune system.
Part of the innate immune system, peripheral blood NK cells, show dynamic
changes in number as well as cytotoxicity during the menstrual cycle, but the
exact nature and consequence of these changes in not yet understood. In the
present study, we characterize the variation in the natural killer cell
receptors associated with different phases of the menstrual cycle in women with
a natural menstrual cycle and also in men. We compare activating and inhibitory
peripheral natural killer cell receptors at strictly defined follicular (day 7)
and luteal (day 21) phases of the menstrual cycle. The results will advance our
understanding of the timing and consequence of the natural hormonal cycle on
immune environment.
Study objective
The main goal of this study is to analyse the influence of the menstrual cycle
on NK cell receptor variability.
Study design
Women and men will be asked to visit the TVDC to sample peripheral blood with a
venapunction at day 1, 7 and 21 of the menstrual cycle during 2 consecutive
cycles. Furthermore, women will be asked to sample menstrual blood at day 1 of
the menstrual cycle during 2 consecutive cycles.
Study burden and risks
The burden of the study is limited to six venapunctions at six different time
points and sampling of menstrual blood. There are no risks associated with
participation and there is no personal benefit for participation. By means of
participation, more knowledge can contribute to gaining more insight in the
influence of the menstrual cycle on the immune system.
Verheylaan 10
Maastricht 6229 HX
NL
Verheylaan 10
Maastricht 6229 HX
NL
Listed location countries
Age
Inclusion criteria
Healthy women between the age of 18 and 36 with no chronic medical conditions,
like chronic hypertension, chronic kidney failure, chronic immune conditions
(SLE) or chronic medication use, with a natural menstrual cycle, defined by no
contraceptive use and healthy women with a copper spiral
Healthy men between the age of 18 and 36 with no chronic medical conditions,
like chronic hypertension, chronic kidney failure, chronic immune conditions
(SLE) or chronic medication use
Exclusion criteria
- Current or recent (<2 weeks) symptomatic infection
- Previous pregnancy with complications, such as repeated miscarriages,
preeclampsia, or diabetes gravidarum
- Unable to give mentally capable consent in Dutch
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL70964.068.19 |