4D MR flow detection of hemodynamic predictors for aneurysm rupture

Growth and rupture of unruptured intracranial aneurysm (UIAs) is a
multifactorial process with hemodynamic stress as important contributor. In the
last years, hemodynamic parameters (such as pressure distribution and wall
shear stress) have been introduced as a promising tool to improve the
prediction of aneurysm rupture [1]. Currently it is difficult to predict
rupture, which limits clinical decision making and patient counselling. For
example; larger posterior circulation aneurysms have a high rupture risks that
typically justifies intervention, but most instances of aneurysmal SAH are
caused by rupture of a relatively low-risk small anterior circulation aneurysms
as these small aneurysms outnumber aneurysms at other locations. Thus, we need
better individual risk prediction for aneurysms to select those that will
rupture.

Relate aneurysm hemodynamics to aneurysm configuration and growth to obtain
insight in the hemodynamic pathophysiology of aneurysm growth in order to
improve prediction of aneurysm rupture.

in a cohort of 40 patients with an unruptured and asymptomatic intracranial
aneurysm of at least 4 mm, who come for their periodic clinical follow-up scan
on the CE-labeled 3T MRI scanner, we will additionally make a 4D flow scan on
the 7T MRI on the same day. Patients are included for a period of 12 months

Subject does not need to come to the hospital extra, the additional scan takes
about 10 minutes and in total (including patient on the scanner and away from
the scanner) the scan will take a maximum of half an hour. The scan will not
need to be reported. The additional scan is scheduled as soon as possible after
the clinical scan. One of the researchers will guide the patient during the
scan. No ionizing radiation is given. No contrast agent is given, and therefore
no IV