The goal of this study is to gain insight into the mechanisms underlying the relation between consumption speed and satiation. This study related chewing duration (short/long) for standard lunches to blood glucose levels in 3 post-lunch hours. Also…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
gezonde voedselkeuze
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primaire study parameter is bloodglucose levels during the 3-hours following a
test lunch consumed following a long/short chewing protocol. Blood glucose
parameters are: time-to-peak, maximum value and area under the curve.
Secondary outcome
Secondary study parameters are salivary amylase and particle sizes of the food
boli at the moment of swallowing.
Background summary
Previous studies demonstrated that food consumed at a slower pace was more
satiating that the same food consumed at a faster pace. Whereas these results
are robust, there is relatively little insight into the underlying mechanisms
of this finding. As a result, this finding has so far not been used for the
development of more satiating and healthier foods.
Study objective
The goal of this study is to gain insight into the mechanisms underlying the
relation between consumption speed and satiation. This study related chewing
duration (short/long) for standard lunches to blood glucose levels in 3
post-lunch hours. Also, the possible mediating roles of particle size in the
food boli at the moment of swallowing, and salivary amylase will be
investigated.
Study design
The study consists of an 8-day trail in which subjects consume two test lunches
following a fast- or short chewing protocol. The testlunches consists of
starch-based foods with varying fiber contents. The order of chewing conditions
is randomized. Before each lunch, two samples of food boli will be collected
for analysis of salivary amylase and particle size.
Intervention
Test subjects will consume two testlunches (rice and chickenpeas) in duplicate
following a short and long chewing protocol.
Study burden and risks
The study is non-therapeutic to the participants. The risk associated with
participation is negligible and compared to other studies the burden can be
considered low.
Bornse Weilanden 9
Wageningen 6708 WG
NL
Bornse Weilanden 9
Wageningen 6708 WG
NL
Listed location countries
Age
Inclusion criteria
* Apparently healthy men and women (based on questionnaire, self-reported)
* Aged between 18 * 55 yrs
* BMI between 18.5 and 30
Exclusion criteria
Participants will be excluded if:
* Employed by the FHCR group of Wageningen Food & Biobased Research.
* BMI > 30.0 en < 18.5
* Diagnosed with Diabetes mellitus type 1 or 2
* Under treatment for neurological or psychiatric complaints, including eating
disorders
* History of gastro-intestinal surgery or having (serious) gastro-intestinal
complaints
* Use of medication/supplements that may influence the study results, such as
medicines known to interfere with glucose homeostasis. This will be judged by
our medical doctor
* Following a diet or gained/lost >=5kg weight in the previous month.
* Coeliac disease or gluten intolerance
* Skin allergy, eczema or known sensitivity for plasters
* use of drugs
* Current smokers
* Using > 14 glasses of alcohol/week
* Having food allergies
* Participation in another clinical trial at the same time
* Gastric emptying disorder.
* Problems with chewing and/or swallowing
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74340.081.20 |