The primary objective of this study is to investigate if the VR-game is able to activate the pathophysiological substrate associated with OCD in OCD patients, as opposed to healthy controls The secondary objective is to investigate the correlation…
ID
Source
Brief title
Condition
- Anxiety disorders and symptoms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters involve (1) the VR-game output scores and (2) brain
activity on fMRI and (3) Y-BOCS scores
Secondary outcome
Not applicable.
Background summary
Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder
characterized by obsessions and repetitive compulsions. To date, a diagnosis of
OCD is based on retrospective and subjective measures. There is a need for
standardized and objective tools to improve diagnostics. Interestingly, virtual
reality (VR) can be used to actively provoke and assess OCD specific symptoms
in a controlled and standardized environment. In a former study, we showed a
virtual reality game (VR-game) designed by our department is capable of
inducing OCD symptoms of self-reported anxiety and compulsive behaviour in OCD
patients. We will now investigate whether the VR-game is able to activate the
pathophysiological substrate of OCD. This will support the objectivity and
specificity of the use of the VR-game as a tool to examine OCD symptoms.
Study objective
The primary objective of this study is to investigate if the VR-game is able to
activate the pathophysiological substrate associated with OCD in OCD patients,
as opposed to healthy controls The secondary objective is to investigate the
correlation between the activity of the substrate and the severity of OCD.
Study design
We will perform a cross-sectional study including 9 OCD patients and 9 healthy
controls. The participants will play the VR-game while time alterations in
blood flow are visualized with fMRI. A comparison between OCD-patients and
healthy controls will be made. Some questionnaires to enable a psychiatric
assessment of the participants and determine the severity of OCD will be
obtained preceding the procedure.
Study burden and risks
The risk associated with participation can be considered negligible and the
burden can be considered minimal. Total participation time is estimated around
3 hours.
Meibergdreef 5
Amsterdam 1105 AZ
NL
Meibergdreef 5
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
- Diagnosis of primary OCD by DSM-IV criteria
- Age between 18-65
Exclusion criteria
- Severe neurological disorders and cardiovascular disorders
- Use of psychiatric medication including tricyclic antidepressants,
antipsychotics and benzodiazepines
- Mental retardation
- Use of medication potentially influencing cerebral blood flow and the
cardiovascular system
- Severe comorbid axis I disorders
- Alcohol or substance abuse during the last 6 months
- Use of alcohol or benzodiazepines in the 24 hours prior to investigation or
recreational drugs in the 72 hours prior to investigation
- Abnormal hearing and uncorrected vision
- Irregular sleep/wake rhythm
- Contraindications for fMRI
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59652.018.16 |