To determine the impact of detubation on changes in electrical activity of the diaphragm in adults, children and neonates.
ID
Source
Brief title
Condition
- Neonatal respiratory disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in electrical activity of the diaphragm before and after detubation.
Secondary outcome
The relation between changes in electrical avtivity of the diaphragm and
detubation failure.
Background summary
The provision of invasive respiratory support with an endotracheal tube (ET) is
a core feature of intensive care medicine. Removal of the ET is the last step
in the weaning process. Detubation is of great importance because failure of
detubation is associated with an increased duration of mechanical ventilation,
prolonged stay on an intensive care unit (ICU), the need of a tracheostomy,
higher mortality rate and higher costs. Various weaning predictors have been
investigated to enable the likelihood of a successful weaning to be assessed as
early and accurate as possible. All these predictors have limited utility in
the predicting the success of detubation.
Studies show that transcutaneous electromyography of the diaphragm (dEMG) is a
reliable basic cardiorespiratory monitor and it is capable to detect changes in
diaphragmatic activity after an intervention. This information might be useful
when weaning a patient from the mechanical ventilation. The aim of this study
is to compare patients successfully separated from the ventilator and the ET
and those who failed, in terms of various dEMG-derived parameters, and to
assess the putative use of such parameters for outcome prediction.
Study objective
To determine the impact of detubation on changes in electrical activity of the
diaphragm in adults, children and neonates.
Study design
Prospective observational cohort study.
Electrical activity of the diaphragm is measured by dEMG before and after
separation of the mechanical ventilator and ET.
Study burden and risks
The study population will not benefit from participating in this research. This
study will expand our knowledge on detubation failure what will benefit future
care for these patients.
Meiberdreef 9 Meibergdreef 9
Amsterdam 1105AZ
NL
Meiberdreef 9 Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
- Mechanical ventilation via an endotracheal tube for at least 24 hours,
whatever the underlying disease and the reason for ventilatory assistance
- The decision to detubate the patient is made by the physician in charge of
the patient.
- The attending phycician considers the patient to be vulnerable to participate
in the study
- Written informed consent from the patient or legal representative(s)
Exclusion criteria
- those for whom life support will be withheld or withdrawn will not be
included in the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58426.018.16 |