To compare retrospectively reconstructed, radially sampled contrast-enhanced MR images of the liver with conventionally acquired contrast-enhanced MR images of the liver in terms of Quality of enhancement (QE), overall image quality (IQ), liver edge…
ID
Source
Brief title
Condition
- Hepatic and hepatobiliary disorders
- Synovial and bursal disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Quality of enhancement (QE), overall image quality (IQ), liver edge sharpness
(HES), hepatic vessel clarity (HVC) and streak artefacts of (A) radially
sampled contrast-enhanced MR images of the liver and (B) conventionally
(clinical) acquired contrast-enhanced MR images of the liver scored by three
experienced abdominal radiologists on a 5 points Likert-scale obtained in
sub-study V.
Secondary outcome
Test-retest reproducibility of quantitative DCE-MRI parameters as derived from
the retrospectively reconstructed, radially sampled contrast-enhanced MR images
of the liver obtained in sub-studies IIIB and IV. Comparison of quantitative
DCE-MRI parameters to diffusion-weighted images (IVIM) and MR elastography.
Background summary
Contrast-enhanced MR scanning plays an important role in the daily clinical
diagnostic work-up of patients. In the abdomen, such scans can be compromised
by respiratory motion artefacts and the impossibility to repeat a contrast
agent administration bolus. New methods are being developed to overcome these
hurdles and allow high quality images in free breathing. Golden-angle based
radial k-space sampling in combination with compressed sensing reconstruction
have been shown to allow imaging in free breathing with high quality DCE
images. The aim of this study is to (I) develop for Philips scanners in the
AMC, (II) implement, (III) test golden-angle based radial k-space sampling in
combination with compressed sensing reconstruction and (IV) compare
contrast-enhanced images reconstructed using this method with conventionally
acquired contrast-enhanced image sets. This should pave the way for these
methods to become available for both clinical and research purposes in the AMC.
Study objective
To compare retrospectively reconstructed, radially sampled contrast-enhanced MR
images of the liver with conventionally acquired contrast-enhanced MR images of
the liver in terms of Quality of enhancement (QE), overall image quality (IQ),
liver edge sharpness (HES), hepatic vessel clarity (HVC) and streak artefacts
as assessed by three experienced abdominal radiologists
Study design
Prospective observational study.
Study burden and risks
Participating in this study leads to no immediate advantage for the individual
participant. However, to be able to develop, implement and improve new
contrast-enhanced MR applications, studies in healthy volunteers with contrast
administration are mandatory. In the future, these newly developed MR methods
are thought to be more patient-friendly and provide better image quality in
comparison to the current methods.
The burden for subjects consists of either 1 × 30 minutes (20 healthy
volunteers), 1 x 45 minutes (15 patients), 2 × 30 minutes (15 healthy
volunteers) or 3 × 30 minutes (15 healthy volunteers) of extra MRI scan-time.
Routine dosages of gadoteerzuur Gd-EOB-DTPA will be administered via an i.v.
line. Adverse reactions to this type of contrast agent are rare. In the
unlikely case of unexpected findings on the MR images (e.g. hitherto
undiagnosed liver lesions), the general practitioner or treating consultant
will be notified.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
For healthy volunteers:
* 18 years or older
* Written, informed consent, For patients:
* 18 years or older
* Scheduled for clinical contrast-enhanced liver MRI
* Written, informed consent
Exclusion criteria
For healthy volunteers and patients:
* General contraindications for MRI (such as pregnancy and claustrophobia)
* History of chronic renal insufficiency
* History of allergic reaction to Gadolinium-containing compounds
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54247.018.15 |