The main aim of the current study is to identify a set of neurobiological markers that contribute to the prediction, distinction and prevention of reactive and proactive aggressive behavior. The study has two primary objectives: 1) to study whether…
ID
Source
Brief title
Condition
- Psychiatric and behavioural symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) The association between sensory processing and aggressive behavior will be
studied. Sensory processing will be measured using a questionnaire.
2) The association between hormonal values (testosterone and cortisol) and
aggressive behavior will be studied. Hormonal values will be obtained from hair
samples.
Aggressive behavior, the main outcome, will be measured by two self-report
questionnaires, resulting in three outcomes: reactive aggressive behavior,
proactive aggressive behavior and total aggressive behavior.
Secondary outcome
-
Background summary
Aggressive behavior has many adverse effects on victims, perpetrators, their
families and society. Nowadays prediction of risk for recidivism is fully based
on psychological and social factors and treatment is centered around
psychotherapeutic interventions. However, fundamental research has shown that
the value of many neurobiological factors in terms of prediction and prevention
of aggressive behavior still remains to be unraveled. Innovative technologies
potentiate research into biological pathways to aggressive behavior. Specific
neurobiological markers of aggressive behavior may provide new insights for
prediction and prevention of such behaviors.
Study objective
The main aim of the current study is to identify a set of neurobiological
markers that contribute to the prediction, distinction and prevention of
reactive and proactive aggressive behavior. The study has two primary
objectives: 1) to study whether sensory processing is associated with
aggressive behavior and 2) to study whether the neuroendocrinological hormones
cortisol and testosterone are associated with aggressive behavior.
Study design
The current study is a longitudinal study in which forensic psychiatric
patients will be compared to a healthy controls of similar age, sex,
educational level and ethnicity. The comparative design makes it possible to
study differences between forensic psychiatric patients and healthy controls.
For the patients, there will be a follow-up measurement one year after the
baseline measurement. This longitudinal design provides the possibility to
study change within persons over time related to treatment progression.
Study burden and risks
All participants will be invited for a baseline visit and an online survey.
Only participants of the patient group will be invited for a follow-up visit
after one year. The baseline part consists of several measurements in the form
of questionnaires, a neuropsychological test and biological measurements such
as length, weight, collection of scalp hair and saliva samples. The risks
associated with all of these measurements are considered to be negligible. The
follow-up visit for patient participants will comprise short repeated
measurements of the main outcome variables. Participants receive a monetary
compensation for their participation. The current study has the potential to
identify several neurobiological markers that may improve the prediction and
prevention of reactive and proactive aggressive behavior and the treatment
progression of forensic psychiatric patients.
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, all patients and controls
must meet the following criteria:
- Participant is at least 18 years old.
- Participant has provided written informed consent.
Only patient participants should also meet the following:
- Patient is receiving outpatient care at De Tender.
Exclusion criteria
Potential patients or control participants who meet any of the following
criteria will be excluded from participation in this study:
- There are indications for intellectual disability (IQ < 70).
- The participant does not speak or read Dutch on a proficient level.
- The participant is incapable of deciding on study participation and therefore
cannot give informed consent.
Only those patients who can explicitly state that he or she knows that he can
refuse participation, that he/she knows what participation in the study
encompasses and that he or she can always, without further questions, withdraw
from the study, are considered capable of participation.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64868.078.18 |