The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
ID
Source
Brief title
Condition
- Other condition
- Central nervous system infections and inflammations
Synonym
Health condition
reukvermogen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in event-related potentials in response to olfactory stimuli between
patients with smell loss and controls
Secondary outcome
Score on the Sniffin' Sticks test (smell test) of participants and its
correlation with N1 and P2 amplitudes of olfactory ERPs.
Background summary
The role of smell is of major importance in flavour perception and eating
behaviour, sensing threats, social interaction and memory processes. The
ability to smell greatly contributes to the quality of life. Loss of olfactory
function is common and affects about 3-20% of the population. Risk of anosmia
(inability to smell) and hyposmia (decreased ability to smell) can result from
neurodegenerative diseases, trauma or infection. Olfactory deficits often go
unnoticed, which highlights the importance of objectively measuring olfactory
function in patients. Recently, EEG has gained clinical interest as a potential
method to distinguish between patients with olfactory loss and healthy
controls. How smell loss correlates with brain activation in response to
olfactory stimuli still needs to be investigated.
Study objective
The primary objective of this study is to investigate the difference in brain
activation in response to odour stimulation between patients and controls. The
secondary objective is to investigate the relationship between smell ability
and brain activation in response to odour stimulation. We hypothesize that
brain responses will decrease with severity of olfactory loss.
Study design
This is an observational study.
Study burden and risks
Participation includes one test session at Hospital Gelderse Vallei in Ede.
Participants are asked to only drink water for two hours before the test
session. At the start of the test session participants need to fill in a short
questionnaire. During the test session olfactory function will be assessed
using the UPSIT-40 (~30 minutes) and an EEG measurement (~60 minutes) will be
performed. EEG is a widely used, non-invasive and safe way to measure brain
activation. An EEG cap will be placed on the participants* head and electrodes
will be connected by using gel and a tool to scratch a bit on the head. This
may feel a bit cold and unpleasant. Participants are asked to sit still and not
move their head during the EEG measurement. During the EEG measurement odour
stimuli will be presented via an olfactometer, which tubes will be inserted ± 1
into the nostrils. The study is non-therapeutic to the participants. The risk
associated with participation is minimal.
Stippeneng 4
Wageningen 6708 WE
NL
Stippeneng 4
Wageningen 6708 WE
NL
Listed location countries
Age
Inclusion criteria
For patients:
* Labelled as hyposmic or anosmic according to a standardised olfactory test
* Smell loss due to a viral infection
* Aged between 18-65 years
* Have normal/ corrected to normal eyesight
* Willing to follow the study procedures
* Having given written informed consent
* Righthanded
For controls:
* Self-reported healthy
* Labelled as normosmic according to a standardised olfactory test
* Aged between 18-65 years
* Have normal/ corrected to normal eyesight
* Willing to follow the study procedures
* Having given written informed consent
* Matched on sex to patient
* Matched on age (within +/- 3 years) to patient
* Righthanded
Exclusion criteria
* Having congenital anosmia (because olfactory networks will be different from
people who have been able to smell)
* Having suffered from head trauma
* Having chronic (neurological) diseases which impact brain functioning (e.g.
mental health disorder, epilepsy)
* Having fluctuating smell ability
* Being deaf (or having hearing problems) or blind
* Being an employee at the division of Human Nutrition and Health at Wageningen
University
* Performing a thesis or internship at the chair group Sensory Science and
Eating Behaviour at the division of Human Nutrition and Health at Wageningen
University
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
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In other registers
| Register | ID |
|---|---|
| CCMO | NL75270.028.21 |