To investigate the functional implications of bacteria, cigarette smoke components and adipokines in the pathology of hidradenitis suppurativa by analyzing the cytokine profiles and the antimicrobial peptide profiles in peripheral bloodsamples of…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
De proefpersonen fungeren als de controle groep van patienten met de huidziekte hidradenitis suppurativa.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the difference of immune response to above
mentioned hidradenitis suppurativa triggering factors, forexample the
cytokine/antimicrobial profile after microbial exposure in HS patients compared
to healthy controls.
Secondary outcome
N.A.
Background summary
Hidradenitis suppurativa is considered a complex disease involving several
factors. The clinical presentation of hidradenitis suppurativa appears
reminiscent of bacterial infection. However, the role of these bacterial
species is poorly understood and is far from resolved. Other important
associated factors are smoking and obesity. In order to gain more insights into
the pathogenesis of hidradenitis suppurativa, especially in the interaction
between commensal flora,cigarette smoke components, adipokines and the immune
system, further exploration is required.
Study objective
To investigate the functional implications of bacteria, cigarette smoke
components and adipokines in the pathology of hidradenitis suppurativa by
analyzing the cytokine profiles and the antimicrobial peptide profiles in
peripheral bloodsamples of patients withhidradenitis suppurativa and healthy
controls.
Study design
Explorative and experimental study
Study burden and risks
The subject will not directly benefit from this research, but participation
contributes to an increase in knowledge about hidradenitis suppurativa and
subsequently improving treatment and care.
Postbus 2040 Dr. Molewaterplein 40
Rotterdam 3015GD
NL
Postbus 2040 Dr. Molewaterplein 40
Rotterdam 3015GD
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria cases - hidradenitis suppurativa patients
- Participating in HiScreen Biobank
- Informed consent available for bloodsamples
Inclusion healthy volunteers
- Adult (>18 years old) not suffering from HS
- Competent and willing to provide informed consent
Exclusion criteria
Exclusion criteria for hidradentis suppurativa patients
- <18 years of age
- use of systemic or local antibiotics in the past 2 weeks
- use of any other medication potentially affecting the cytokine/antimicrobial
profiles
- pregnant women
Exclusion criteria controls
- <18 years of age
- known with hidradenitis suppurativa
- use of any other medication potentially affecting the cytokine/antimicrobial
profiles
- pregnant women
- relatives with hidradenitis suppurativa
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL76820.078.21 |