To investigate the breathing patterns of asthma patients during exercise, compare this with the breathing pattern of healthy subjects and investigate whether the breathing pattern influences EID in patients with asthma.
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the breathing pattern. The breathing pattern is
defined as the relative contribution of the breathing frequency (Bf), tidal
volume (Vt), abdominal breathing and thoracic breathing to the respiratory
minute volume and how these change during physical exercise. These parameters
will be compared between all subjects and cluster analysis will be performed in
order to define different breathing patterns.
Secondary outcome
The secondary goal of the study consist of the investigation whether certain
breathing patterns can lead to EID. The level of dyspnoea will be objectified
using BORG and visual analog scale (VAS) scores.
Background summary
Among the roughly 273 million people suffering from asthma worldwide, exercise
induced dyspnoea (EID) is a common complaint. Additionally, 29% of patients
with asthma also suffer from dysfunctional breathing (DB) (an atypical
breathing pattern leading to medical complaints) which is one of the main
contributors to EID. However, EID is often attributed to exercise induced
bronchoconstriction (EIB) and the possible effect of dysfunctional breathing on
EID is unknown. Therefore, this study will investigate the breathing patterns
of patients with asthma and compare these with the breathing patterns of
healthy subjects using the Hexoskin smart shirt with integrated respiratory
inductance plethysmography (RIP) sensors.
Study objective
To investigate the breathing patterns of asthma patients during exercise,
compare this with the breathing pattern of healthy subjects and investigate
whether the breathing pattern influences EID in patients with asthma.
Study design
The study will have an observational cross-sectional design. The study will
compare the breathing pattern of asthma patients and healthy subjects during a
VO2-max cycling ergometry test. Prior to the cycling ergometry test, salbutamol
will be administered to the asthma patients to reduce the effect of EIB. The
level of EIB will be objectified with lung function tests (Spirometry and
forced oscillation technique (FOT).
Study burden and risks
The risk for adverse events due to participation in this study is minimal.
Subjects will undergo measurements according to the standard protocol as used
in clinical care. Because of the small risks concerning a VO2max cycling
ergometry test, the subjects will be constantly monitored by a physician.
Koningsplein 1
Enschede 7512KZ
NL
Koningsplein 1
Enschede 7512KZ
NL
Listed location countries
Age
Inclusion criteria
Asthma group:
- Confirmed asthma diagnosis by a health professional
- Patient using inhalaled corticosteroids
- Normal lung function under treatment (FEV1>80% predicted post salbutamol)
- Age 18-60
Healthy groep:
- No pulmonary disease
- No usage of lung related medication
- Age 18-60
Exclusion criteria
- Asthma exacerbation within 6 week before inclusion (asthma group only)
- More than 10 pack-years
- Pulmonary disease other than asthma
- Neurological or muscular disorder
- Meets one of the contra-indications mentioned in the cycling ergometry
protocol from MST
- Has been tested postively for covid-19 in the past 3 months or has not fully
recovered from an earlier covid-19 infection
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL75829.100.20 |
| OMON | NL-OMON24296 |