To evaluate whether we can determine the health status of the joint by measuring biomarker levels using a newly developed assay by the University of Twente based on the multiplex measurement of a panel of relevant biomarkers using Surface Plasmon…
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome of the study is the relationship between biomarker levels
and joint health status.
Secondary outcome
The secondary outcome of the study is the correlation between biomarker levels
in serum and synovial fluid.
Background summary
Since no curative treatment for osteoarthritis (OA) exists, considerable
efforts aim to develop treatments that can inhibit progressive cartilage
degeneration and cure OA. To assess the efficacy of potential new treatment
options, subjective reduction of complaints is used as outcome measure since no
objective and realistic outcome measures are currently available. Particularly
there is a pressing demand for so called biomarkers and biomarker assays that
can be used to assess bodily fluids and in particular the synovial fluid to
objectively assess the health status of the affected joint. It is believed that
such assay would enable distinction between OA phenotypes. Therefore, there is
a pressing clinical demand to determine joint degeneration and to predict
disease progression by objective measures. Ideally, this assay could also be
used to diagnose early stage OA once treatment options to prevent progression
are available.
Study objective
To evaluate whether we can determine the health status of the joint by
measuring biomarker levels using a newly developed assay by the University of
Twente based on the multiplex measurement of a panel of relevant biomarkers
using Surface Plasmon Resonance imaging (SPRi).
Study design
Single-center, observational study.
Study burden and risks
Synovial fluid and blood will be collected when patients come to the hospital
for treatment. Synovial fluid aspiration will be performed when the joint is
accessed as part of standard treatment, therefore, no additional puncture into
the joint is needed.
Nico Bolkesteinlaan 75
Deventer 7416SE
NL
Nico Bolkesteinlaan 75
Deventer 7416SE
NL
Listed location countries
Age
Inclusion criteria
- Patient will undergo knee arthroscopy, intra-articular injection in the knee,
or partial or total knee replacement surgery;
- Patient is willing and able to provide informed consent for the study.
Exclusion criteria
- Contra-indications to undergo knee arthroscopy, intra-articular injection in
the knee, or partial or total knee replacement.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL77776.075.21 |