Primary Objective: Does DBS result in cognitive changes in patients with OCD on the long term? Secondary Objective(s): Does DBS result in personality changes in patients with OCD on the long term?Are certain cognitive profiles associated with…
ID
Source
Brief title
Condition
- Anxiety disorders and symptoms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Outcomes on a (neuro)psychological test battery
Secondary outcome
Personality variables measured with the Young Schema Questionnaire.
Background summary
Around 60% of people that are diagnosed with a treatment resistant
Obsessive-compulsive improve after treatment with DBS.
A recent survey amongst patients in the Amsterdam UMC has shown that at least
50% of patients have subjective complaints of cognitive decline following DBS.
Furthermore, before the surgery, many patients are concerned about personality
changes. Literature on cognitive functioning and personality following DBS is
scarce. The aim of the current study is to follow-up on the cognitive
functioning and personality changes of OCD patients who were treated with DBS.
Study objective
Primary Objective:
Does DBS result in cognitive changes in patients with OCD on the long term?
Secondary Objective(s):
Does DBS result in personality changes in patients with OCD on the long term?
Are certain cognitive profiles associated with clinical outcome of patients?
Are certain personality traits or schemas associated with the outcome of DBS or
cognitive functioning on the long term?
Study design
The study is a cross-sectional observational study, combined with a
retrospective chart study. All patients have been treated with DBS for OCD. For
the current study, a (neuro)psychological test battery will be administered
once in a single session to establish current (neuro)psychological functioning.
This session will last a maximum of 2 hours and will take place in the
Amsterdam UMC, location AMC. Results of these (neuro)psychological tests will
then be compared with the results of the tests that were administered before
DBS -during the standard intake- to establish whether there is cognitive
decline.
Study burden and risks
There are no risks associated with participating in this study. The burden is
restricted to a one time visit to the Amsterdam UMC to ondergo a
neuropsychological test battery for about 120 minutes. There are no direct
benefits for the participating subjects.
Meibergdreef 5
Amsterdam 1105 AZ
NL
Meibergdreef 5
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
- Patients are treated with vALIC DBS for OCD for at least one year.
- Written informed consent must be obtained before participation.
Exclusion criteria
- Current substance abuse (excluding nicotine abuse)
- Diagnosed comorbid conditions that can influence cognitive functioning or
personality, such as dementia, Parkinson*s disease, or haemorrhage.
- Insufficient knowledge of the Dutch language to understand the test
instructions.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75894.018.21 |