Detecting and quantifying the cardiac cycle-related pulsatility of the intracranial aneurysm wall with 4D CTA. Besides, the pulsating belbs will be differentiated from noise-induced pulsations.
ID
Source
Brief title
Condition
- Aneurysms and artery dissections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The presence of cardiac-cycle related pulsatile blebs of the intracranial
aneurysm wall.
Secondary outcome
quantification of the pulsatile behaviour of the entire aneurysm dome and the
vascular tree motion. Comparison between two differenct CT scanners.
Background summary
Intracranial aneurysm (IA) wall motion is proposed to indicate locations with
reduced stability. If reliable measurements of the pulsatility could be
performed, increased pulsatile wall motion could be a valuable addition to the
current rupture risk estimation. The magnitude of the pulsations is unknown,
impeding the validation of IA pulsations.
Study objective
Detecting and quantifying the cardiac cycle-related pulsatility of the
intracranial aneurysm wall with 4D CTA. Besides, the pulsating belbs will be
differentiated from noise-induced pulsations.
Study design
Observational pilot study.
Study burden and risks
A radiation dose of 3 mSv is added and there is a risk for side effects of the
contrast agent. This study contributes towards a refined rupture risk estimated
in patients with unruptured and untreated aneurysms.
Geert Grooteplein-zuid 30
Nijmegen 625GA
NL
Geert Grooteplein-zuid 30
Nijmegen 625GA
NL
Listed location countries
Age
Inclusion criteria
1. Adult patients with untreated and unruptured intracranial aneurysm(s).
2. Planned for a follow-up scan in the Radboudumc
3. Informed consent.
Exclusion criteria
1. Contra-indications for CT or contrast agent (pregnant, patients with an
allergic reaction to contrast agent or patients with Kahler's or Waldenstrom's
syndrom)
2. Aged below 18 years or mentally incompetent.
3. Patients with impaired kidney function, at least eGFR <60 ml/min/1.73m2;
4. Patients with coiled aneurysms at the same height as the untreated aneurysm.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75245.091.20 |
| Other | NL8936 |