In a way, the turbulence elicited by blood passing the stenotic valve can be seen as 'labeling' the ejection phase of the heart. This makes it possible to distinguish this phase from the presumed phase of arterial contraction. Systematic…
ID
Source
Brief title
Condition
- Cardiac valve disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The presence or absence of turbulence in blood flow velocity measurements in
proximal are distal arteries.
De phase during systole that turbulence is observed.
Secondary outcome
timing of stroke onset at different measuring points in the arterial system
with respect to the R-peak of a simultaneously recorded QRS-complex
Background summary
Blood flow velocity measurements in patients with congenital aortic valvular
stenosis contains a certain amount of turbulence when measured distal to the
stenosis. This turbulence spreads over the arterial tree and can be measured or
heard by means of duplex ultrasonography.
In the past a single subject observation was made that this turbulence does not
contain the full duration of systole but may be preceded by a brief period of
non/turbulent or laminar flow. This observation, when confirmed in a larger
series, may provide new insight in the physiology of the cardiovascular system.
It may support the theory of acceleration, formulated in 2014, that during the
first few instances the ejection phase of the heart is supported by a brief
contraction within the arterial tree that travels like a peristaltic wave along
its branches enabling the pressure of cardiac contraction to reach out into all
the bodies capillary systems.
Study objective
In a way, the turbulence elicited by blood passing the stenotic valve can be
seen as 'labeling' the ejection phase of the heart. This makes it possible to
distinguish this phase from the presumed phase of arterial contraction.
Systematic research describing these two phases may provide support or denial
to the theory of arterial acceleration.
Study design
Measuring bloodflow velocity in different locations within the arterial tree in
patients with a congenital aortic valve stenosis who are enlisted for aortic
surgery. Patients with a severe aortic valve stenosis will be operated (valve
replacement or valve reconstruction). The patients will be examined prior to as
well as after surgery. Patients with a moderate stenosis will not be operated
but are nevertheless investigated twice with a 3 month interval. Finally, a
control group of patients without aortic valve stenosis will also be
investigated twice with a 3 month interval.
By describing flow velocity patterns qualitatively measurements are assessed on
the presence of turbulence within proximal and distal arteries. By comparing
preoperative with postoperative measurements it will be investigated whether
turbulence decreases as expected after succesfull surgery.
Study burden and risks
Participants are twice asked to come to the Martini Hospital in Groningen for
an ultrasound investigation of 90 min. duration.
v. Swietenplein 1
Groningen 9728 NT
NL
v. Swietenplein 1
Groningen 9728 NT
NL
Listed location countries
Age
Inclusion criteria
moderate (5) or severe (5) congenital valvular aortic stenosis or patients who
were proven to have no valvular aortic stenosis (5)
Exclusion criteria
atrial fibrillation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL77569.042.21 |