The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Automatic quantified acoustic aspects of speech (e.g duration of pauses,
changes in pitch and mean sentence lengths) and complex tests scores at the
different linguistic levels phonology, semantics and syntax selected for
language production and comprehension.
Secondary outcome
We will relate speech characteristics and test scores from the DIMA to the
severity of positive, negative and cognitive psychosis symptoms.
Background summary
Currently, the field of psychiatry is lacking reliable biomarkers to provide
reproducible information on (early) diagnosis and relapse prediction. This
translates to treatment delay. In addition, relapses are difficult to predict
and therefore can currently not well be prevented. Analysis of spontaneous
speech can provide such a marker. Speech parameters reflect important brain
functions such as motor speed (acoustic analyses), emotional status
(sentiment), cognitive functioning (use of grammar/syntax), and formal thought
disorder (coherence). An impairment of verbal communication is one of several
diagnostic features of psychiatric disorders, including depression, psychosis
and autism.
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Study objective
The aim of this study is to combine acoustic characteristics from spontaneous
speech and results from tests at different linguistic levels e.g. the
Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in
speech are most indicative for psychosis.
Study design
An observational study of automatic quantified acoustic aspects of speech (e.g
duration of pauses, changes in pitch and mean sentence lengths) and complex
tests scores at the different linguistic levels phonology, semantics and syntax
selected for language production and comprehension.
Participants have to fill in one questionnaire, and to perform two speech
tasks. A psychiatrist will perform a structured interview (PANSS) to assess
psychotic symptoms. The total duration the assessments will be around 75
minutes.
Potential confouders will be taken into account.
Study burden and risks
Subjects will be evaluated and provide written informed consent. The task does
not cause a significant discomfort or risk for the subject. There is no direct
benefit for the participant. The participant receive a financial compensation
for participation.
In a recent survey, individuals with psychiatric symptoms (n=675) were
positive about the implementation of automatic speech analysis (Brederoo et
al., 2021). Respondents indicated a preference for speech recordings in the
presence of a clinician as opposed to a recording made at home given the
privacy sensitive nature of this measure.
dr. Molenwaterplein 40
Rotterdam 3000 CA
NL
dr. Molenwaterplein 40
Rotterdam 3000 CA
NL
Listed location countries
Age
Inclusion criteria
1. All participants must give signed informed consent;
2. Participants have a psychotic disorder classified according to DSM-5;
3. Participants are 16-46 years
Exclusion criteria
1. Unable to give informed consent to all aspects of the study;
2. Unable to speak and be interviewed in Dutch;
3. Neurological comorbidities affecting speech, e.g. brain haemorrhage.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80809.078.22 |