Primary Objective: To test the feasibility of online neuropsychological assessments using the Amsterdam Cognition Scan (ACS) compared to classical neuropsychological assessments in patients with cancers with CNS involvement.
ID
Source
Brief title
Condition
- Metastases
- Structural brain disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will calculate completion rates for the classical neuropsychological test
outcomes and for the ACS test outcomes. The completion rate for each test
outcome of the ACS, is considered acceptable when at most 10% lower than the
completion rate of the equivalent classical neuropsychological test.
Secondary outcome
n.a.
Background summary
Cognitive testing with classical neuropsychological assessments is
time-consuming and labor-intensive for patients and test administrators. Online
testing of cognitive functioning offers an attractive alternative to collect
cognitive data for research purposes and for monitoring and exploring cognitive
functioning in clinical settings. The Amsterdam Cognition Scan (ACS) is an
online neuropsychological test battery that was designed to measure the same
cognitive constructs as classical neuropsychological tests. We have extensively
tested and evaluated the ACS in patients who have cancers without central
nervous system (CNS) involvement and healthy controls. Currently, the ACS is
used in 15 clinical trials and normative data have been acquired in 600 healthy
controls. In these populations, we have shown that assessing cognitive
functioning with the ACS is highly feasible and its psychometric properties are
comparable to classical neuropsychological assessments. However, because
cognitive impairments (including motor impairments) are often more severe in
patients with cancers with CNS involvement than those who have cancers without
CNS involvement, we now aim to evaluate the feasibility of administering the
ACS in patients with brain metastases. Because the ACS is designed for
unsupervised assessment (e.g., at the patient*s home), we will administer the
ACS onsite mimicking unsupervised assessment, but in the presence of a test
administrator to observe the patients. This will allow us to formulate, if
necessary, recommendations for adaptation of the ACS to enable unsupervised
administration of the ACS in patients with cancers with CNS involvement.
Study objective
Primary Objective: To test the feasibility of online neuropsychological
assessments using the Amsterdam Cognition Scan (ACS) compared to classical
neuropsychological assessments in patients with cancers with CNS involvement.
Study design
Observational study. Within subject design. Order of classical and online test
battery counterbalanced. One session
Study burden and risks
Taking part in the study takes time, and some neuropsychological tests can be
difficult. This can sometimes be experienced as a disadvantage. There are no
risks associated with participation.
Plesmanlaan 121
Amsterdam 1066 CX
NL
Plesmanlaan 121
Amsterdam 1066 CX
NL
Listed location countries
Age
Inclusion criteria
Patients diagnosed with >= 1 brain metastases
Scheduled for, or treated with stereotactic radiotherapy
Age range 18-89
Exclusion criteria
Insufficient command of the Dutch language
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80205.031.22 |