The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD.
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome will be the electrically evoked isometric quadriceps muscle
endurance (fatigue resistance) and voluntary isokinetic (work fatigue index5)
and isometric quadriceps endurance (time to fatigue).
Secondary outcome
• Involuntary (electrically evoked) assessed muscle force, early and half
relaxation times, 20/50 Hz ratio and normalized maximal rate of force rise
(MFR) of the quadriceps
• Voluntary assessed isokinetic total work and work fatigue index10
• Fatigue using the CIS-fatigue
Background summary
Quadriceps muscle endurance is reduced in patients with COPD. However, no
consensus has been reached yet on the best method to evaluate quadriceps muscle
endurance. One important aspect is the large variety in protocols and devices
used around the world. Commonly used and reliable measures are voluntary
protocols performed on a computerized dynamometer. However, these voluntary
measurements might also be influenced by external factors as patients effort or
motivation. Therefore, it is important to evaluate the relation between
voluntary and involuntary (i.e. electrical stimulated) assessed quadriceps
muscle endurance.
Study objective
The primary objective is to assess the relation between involuntary and
voluntary assessed quadriceps muscle endurance in patients with COPD.
Study design
Cross-sectional observation study.
Study burden and risks
BURDEN: All measurements are part of standard care, except for one
questionnaire and (involuntary) electrical assessed quadriceps function. Thus,
the additional burden for the patient is one additional measurement of
approximately 70 minutes.
RISKS: Performance of electrically evoked assessment of muscle function is not
associated with a health risk. This procedure is non-invasive and not painful
and performed routinely at the department of Physiology (Radboudumc, Nijmegen).
Therefore, no safety risk is involved.
BENEFIT: The benefits will be high as it will provide more insight in the
relation between voluntary and involuntary assessed quadriceps muscle
endurance. This insight is necessary to optimize the clinical assessment of
muscle endurance in patients with COPD.
GROUP RELATEDNESS: This will be the first study in which the relation between
voluntary and involuntary assessed quadriceps muscle endurance in COPD will be
investigated. These results will also be valuable for other diseases/conditions
in which isolated muscle endurance should be assessed like asthma, pulmonary
hypertension, etc.
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
• COPD, based on GOLD classification
• Clinically stable according to the pulmonary physician, i.e. no exacerbation
and/or hospitalization within the previous 4 weeks
• Age between 40-80 years
Exclusion criteria
• Inability to understand the Dutch language
• Musculoskeletal and neurological problems influencing quadriceps muscle
function testing
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80842.091.22 |