To determine changes in brain activity in responses to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Fysiologie van voedselverwerking.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
rCBF in a priori defined homeostatic and reward-related brain regions of
interest (ROIs; hypothalamus, striatum).
Secondary outcome
Seed-based functional connectivity of the ROIs.
Plasma glucose and insulin.
Gastric content volume.
Background summary
The brain is crucial in the regulation of energy intake and maintaining
homeostasis which is subserved by an interaction of homeostatic and
reward-related brain areas. These brain areas integrate multiple neural and
hormonal signals related to energy content such as sweet taste and food reward
in the form of ingested energy. Sugar-sweetened soft drinks have been shown to
contribute to overconsumption and obesity. Therefore, there is great consumer
interest in drinks with low-caloric sweeteners because they do not contribute
to energy intake while still providing the hedonic experience of sweet taste.
However, different low-caloric sweeteners may have differential effects on the
brain because of (subliminal) taste difference and their different metabolic
fate. We hypothesize that the brain and glycemic responses to drinks sweetened
with sugar and different low-caloric sweeteners will be different. This may
have implications for their reward value.
Study objective
To determine changes in brain activity in responses to the ingestion of
flavored waters sweetened with either the nutritive sugar sucrose or different
low-caloric sweeteners.
Study design
Randomized crossover design with six treatments.
Study burden and risks
The study poses no risks to the participants. Each participant will take part
in a screening session (30 min) and in six intervention sessions (100 min),
which require an overnight fast, placement of a canula in an antecubital vein,
6 blood withdrawals (in total 60 mL per visit for 5 visits) and multiple MRI
scans over an hour. These measurements carry minimal risk. The burden is
considered minimal. There is no direct benefit to the participants.
Stippeneng 4
Wageningen 6708WE
NL
Stippeneng 4
Wageningen 6708WE
NL
Listed location countries
Age
Inclusion criteria
- Age between 18 and 30 years
- BMI between 18.5 and 25 kg/m2
- Apparently healthy (self-reported)
- Right-handed
- Sufficient blood hemoglobin (Hb) levels (women > 7,5; men > 8.5 g/dl) and
having antecubital veins suitable for blood sampling via a catheter
- Willing to be informed about incidental findings of pathology and consenting
to informing their general practitioner about this.
Exclusion criteria
- Having disturbances of glucose metabolism such as being prediabetic or
diabetic
- Use of medication that could influence study results including
insulin/metformin/proton pump inhibitors, antacids, anti-depressants
- Allergy or intolerance for any of the study products/compounds (sucrose,
sucralose, stevia extraxt, allulose, monk fruit extract)
- Being a regular smoker (smoking more than one cigarette or e-cigarette with
nicotin per day)
- Drinking more than 14 glasses of alcohol a week
- Having genetic, psychiatric or neurological diseases affecting the brain
- Gastric disorders or regular gastric complaints (more than once per week),
for example heart burn
- Having renal or hepatic disease
- Using recreational drugs more than once per week (e.g. marihuana, XTC, GHB,
laughing gas)
- Having given a blood donation in the past two months
- Being pregnant, lactating or planning on becoming pregnant during the study
- Currently following or having followed calorie-restricted diet in the past
two months
- Participating in other research during the study period
- Not having a general practitioner
- Being an employee or student of the Division of Human Nutrition and Health
- Having a contra-indication to MRI scanning, including, but not limited to:
o Pacemakers and defibrillators
o Intraorbital or intraocular metallic fragments
o Other metal objects on/in the head which cannot be removed
o Ferromagnetic implants
o Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | Het onderzoek zal voor aanvang worden geregistreerd in Clinicaltrials.gov |
| CCMO | NL81742.091.22 |