The goal of this study is therefore to investigate whether the ingestion of mealworm protein can stimulate muscle protein muscle growth after a single endurance exercise session.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Postprandial muscle protein synthesis rates (0-6h)
Secondary outcome
Postprandial muscle protein synthesis rates (0-3 en 3-6h)
Plasma glucose, insuline en aminozuurconcentrations + corresponding peakvalues
and (i)AUC
Plasma 13C6-phenylalanine enrichments
Background summary
Muscle tissue consists of proteins. These proteins are built up of small
building blocks: amino acids. By consuming enough protein in our diet, we make
sure that the body is provided with enough amino acids to facilitate muscle
protein building. Providing the growing world population with sufficient animal
derived protein is a challenge. Edible insects can be produced on a more
sustainable commercial scale than conventional animal derived proteins and
therefore, can contribute to feeding our future population. So far, little is
known about the protein and amino acid composition of edible insects.
Study objective
The goal of this study is therefore to investigate whether the ingestion of
mealworm protein can stimulate muscle protein muscle growth after a single
endurance exercise session.
Study design
randomized, counter-balanced, cross-over design in which males and females will
ingest either an insect protein shake or a non-caloric placebo after endurance
exercise
Intervention
Mealworm protein (bolus based on bodyweight)
running
Study burden and risks
The burden and risks associated with participation are moderate. Insertion of
the catheters are comparable to a blood
draw and could result in a small hematoma. taking in total 8 biopsies within 1
study is a lot, but this is in total 4 per day with at least 2 weeks of
recovery in between. Earlier we have taken up to 6 biopsies on 1 day. Muscle
biopsies will be taken under local anesthesia by an experienced physician, but
may cause some minor discomfort for maximally up to 24 h after completion. The
discomfort is comparable to muscle soreness or the pain
one has after bumping into a table. Also there is a possibility of additional
bleeding after the biopsies. We will take 26 times blood samples (280 mL
total) during the experimental trials. The total amount of blood we draw is
about half the amount of a blood donation and will be completely restored in
approximately 1 month. Participants come to the university twice: 1 screening
(3 hours) and 2 experimental trials (entire day). For both
the screening and the experimental trial, participants have to be fasted, so
they are not allowed to eat and drink (except for water) from
22h00 the evening before. Also, 3 days prior to the experimental trial
participants should keep their diet as constant as possible, do not
perform any type of intense physical exercise, and do not consume alcohol.
During the screening we will perform a DEXA and a maximal running
test. Furthermore, we will ask the participants to fill out a medical
questionnaire and record their food intake and activity for 2 days prior
to the experimental trial. During the experimental trial, we will collect
muscle and blood samples, and participants have to perform
running exercise and consume a protein or placebo drink. There is no direct
benefit for the participants, only their contribution to scientific
knowledge. The participants will get more insight in their body composition and
sports performance (VO2max).
Universiteitssingel 50
Maastricht 6229ER
NL
Universiteitssingel 50
Maastricht 6229ER
NL
Listed location countries
Age
Inclusion criteria
* Age between 18 and 35 y inclusive
* BMI between 18.5 and 30 kg/m2
* Having given informed consent
Exclusion criteria
* Participating in a structured (progressive) exercise program
* Smoking regularly
* Allergy to house dust mites or crustaceans
* Diagnosed GI tract disorders or diseases
* Diagnosed musculoskeletal disorders
* Diagnosed metabolic disorders (e.g. diabetes)
* Cardiovascular disease
* Hypertension (blood pressure above 140/90 mmHg)
* Donated blood 3 months prior to testday
* Pregnant
* Amenorrhea
* Using third generation oral contraceptives
* Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
* Chronic use of gastric acid suppressing medication
* Chronic use of anti-coagulants
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80030.068.21 |